PHARMACOLOGICAL MANAGEMENTS 💊

Question 1

Pharmacological Mgt for DWARFISM: Recombinant GH - it promotes linear growth and increases
muscle mass

Answer 1

SOMATROPIN

Question 2

Pharmacological Mgt for DIABETES INSIPIDUS: used in Central DI and a nasal spray. It reduces urine output and corrects dehydration

Answer 2

DESMOPRESSIN

Question 3

Pharmacological Mgt for DIABETES INSIPIDUS: TIAZIDE DIURETICS - used in Nephrogenic (kidney) DI

Answer 3

Hydrochlorothiazide (helps kidney to reabsorb water)

Question 4

Pharmacological Mgt for DIABETES INSIPIDUS: NSAID- enhances renal response to ADH (common in Nephrogenic DI)

Answer 4

Indomethacin

Question 5

Pharmacological mgt for DM TYPE 2: increases insulin sensitivity

Answer 5

METFORMIN

Question 6

Pharmacological mgt for DM TYPE 1

Answer 6

Insulin Therapy

Question 7

Pharmacological mgt for CUSHING’S SYNDROME: an antifungal medication that inhibits cortisol production

Answer 7

Ketoconazole (main function is anti-fungal, it stops the adrenal gland) (not first line treatment)

Question 8

Pharmacological mgt for CUSHING’s SYNDROME: blocks cortisol production

Answer 8

Metyrapone

Question 9

Pharmacological mgt for CUSHING’s SYNDROME: inhibits adrenal gland function

note: given to pt that has lump. Stops the hyperactive lump.

Answer 9

MITOTANE

Question 10

Pharmacological mgt for ADDISON’S DISEASE: replaces cortisol to support metabolic function also used to combat ADDISON CRISIS

Answer 10

Hydrocortisone

Question 11

Pharmacological mgt for ADDISON’S DISEASE: replaces aldosterone to maintain sodium balance and BP

(note: when taking corticosteroids, the pt should eat first due to they are GI irritant and cold to the stomach.

Answer 11

Fludrocortisone

Question 12

Pharmacological mgt for HYPERTHYROIDISM: blocks iodine incorporation to inhibit thyroid hormones synthesis

action: decreases the secretion of thyroid hormone
it is NOT SAFE FOR PREGNANT WOMEN due to its teratogenic effect.

Answer 12

Methimazole (Tepizole)

Question 13

Pharmacological mgt for HYPERTHYROIDISM: inhibits thyroid hormone synthesis and block conversion of T4 to T3

action: same with Methimazole & it is SAFE for pregnant women

Answer 13

Propylthiouracil (PTU)

Question 14

Pharmacological mgt for HYPERTHYROIDISM: symptomatic relief for cardiac manifestations (normalizes the contraction of the heart)

Answer 14

BETA BLOCKERS (Propranolol)

Question 15

Pharmacological Mgt for HYPOTHYROIDISM: first line treatment for hypothyroidism

Answer 15

Levothyroxine (Synthroid)

note! this is taken in the MORNING because one of its SIDE EFFECTS is INSOMNIA.

also, taken in the MORNING WITH EMPTY STOMACH for BETTER ABSORPTION

Question 16

ANOTHER Pharmacological Mgt for HYPOTHYROIDISM

Answer 16

STOOL SOFTENERS

Question 17

Pharmacological Mgt for HYPOTHYROIDISM: T3 replacement (but depends on where is the decreased T3 and T4) [lifetime medication for pt. that has undergone THYROIDECTOMY]

Answer 17

Liothyronine (Cytomel)

(same with Levothyroxine)

Question 18

Pharmacological mgt for SIADH: reduces renal sensitivity to ADH

Answer 18

Demeclocycline

Question 19

Pharmacological mgt for SIADH: Vasopressin Receptor Antagonist that blocks ADH action,
promotes water excretion without sodium loss

Answer 19

Tolvaptan

Question 20

Pharmacological mgt for SIADH: promote diuresis and correct hyponatremia

Answer 20

Loop Diuretics

Question 21

Pharmacological Mgt for GIGANTISM: Short Term Duration Somatostatin analog that inhibits GH secretion by mimicking somatostatin

Answer 21

OCTREOTIDE

Question 22

Pharmacological Mgt for GIGANTISM: Long Term Duration Somatostatin analog that inhibits GH secretion by mimicking somatostatin

Answer 22

LANTREOTIDE

Question 23

Pharmacological Mgt for GIGANTISM: Dopamine agonist- suppresses GH secretion

Answer 23

CABERGOLINE

Question 24

Pharmacological Mgt for GIGANTISM: Growth Hormone receptor antagonist that blocks GH action at the receptor level, reducing IGF-1

Answer 24

PEGVISOMANT