CAUSES OF THE ENDOCRINE DISORDERS Flashcards
pituitary adenoma, genetic mutations, hypothalamic tumors
GIGANTISM
• Hypothalamus or pituitary gland dysfunction
• Achondroplasia
DWARFISM
• Central DI (hypothalamus & pituitary)
• Nephrogenic DI (kidney)
• Gestational DI (pregnancy)
DIABETES INSIPIDUS
• CNS (trauma, head injury, stroke, brain tumors)
• Medications (antidepressants, antipsychotics)
SIADH
Hashimoto’s thyroiditis, iodine deficiency, thyroidectomy
HYPOTHYROIDISM (Primary) [THYROID GLAND DYSFUNCTION]
insufficient TRH production (thyrotropin releasing hormone)
HYPOTHYROIDISM (Tertiary) [HYPOTHALAMIC DYSFUNCTION]
insufficient TSH production (thyroid stimulating hormone)
HYPOTHYROIDISM (Secondary) [PITUITARY DYSFUNCTION]
• Grave’s disease (autoimmune)
• Toxic nodular goiter
• Thyroiditis
• Excessive iodine intake
• Pituitary tumors (rare)
HYPERTHYROIDISM
• Autoimmune destruction (Grave’s Disease)
• Infections
• Adrenal tumors
• Chronic use of corticosteroids
• Genetic factors
ADDISON’S DISEASE
• Exogenous (prolonged use of corticosteroid)
• Pituitary adenomas
• Adrenal tumors
CUSHING’S SYNDROME
• Autoimmune reaction
• Genetics
• Environmental triggers toxins, infection
DM TYPE 1
• Insulin resistance
• impaired insulin secretion
• Genetic factors
• Environmental and lifestyle factors
DM TYPE 2