PHARMACOLOGICAL EFFECTS - Calcium channel blockers

Question 1

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (1)

Answer 1

Vasodilating effect: improvement of coronary, cerebral, renal blood flow,
↑ microcirculation in the limbs, ↓ preload on the heart.

Question 2

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (2)

Answer 2

Antihypertensive effect : (reduced heart rate)

Question 3

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (3)

Answer 3

• Antianginal action: Expansion of coronary vessels → delivery of oxygen to the heart;
• improve subendocardial blood flow, microcirculation and transcapillary metabolism in the heart muscle, collateral blood supply.

Question 4

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (4)

Answer 4

Antiarrhythmic action: decrease heart rate, ectopic foci in the atria and the velocity of the conduction through the atrioventricular node.

Question 5

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (5)

Answer 5

Nephroprotective: ↑ intrarenal hemodynamics

↓ renal hypertrophy and proliferation of mesangial cells

Question 6

PHARMACOLOGICAL EFFECTS - Calcium channel blockers (6)

Answer 6

Diuretic effect: with a single and prolonged administration of nifedipine and verapamil, an increase in the excretion of water and electrolytes after salt loading; Indapamide is a diuretic.