Others drugs of antianginal classification

Question 1

Adverse β-Blocker Adverse Effects

Answer 1

bronchospasm;
bradycardia, CH, AV blockade, hypotension;
↓ peripheral, cerebral blood flow - weakness, fatigue;
metabolic disorders: increased atherogenesis, hypoglycemia
dyspeptic symptoms;
Applied for the treatment of coronary artery disease on the background of hypertension and tachyarrhythmias, appropriate combination with nitrates.

Question 2

Antihypoxants

Answer 2

myocardial tolerance hypoxia;
in conditions of chronic hypoxia, cause the activation of anaerobic processes and inhibits aerobic;
inhibit tissue respiration;
show efficiency at a widespread sclerosis of coronary vessels, intended for military purposes

Question 3

Ivabradine (coraxan) - selective If – inhibitor

Answer 3

specific blocker of incoming ion current through mixed Na / K channels, which
- determines the pacemaker activity,
- activated at the time of hyperpolarization, participate in the occurrence of a phase of spontaneous slow diastolic depolarization in the sinus node cells
determines the heart rate.

Question 4

Drugs increasing the delivery of O2 to the myocardium

Answer 4

Vasodilator drugs of myotropic action: 
Dipyridamole (Curantil), carbocromen. increases the volumetric rate of coronary blood flow and O2 delivery, 
increase the number of collaterals;
have antiplatelet effect;
reduce blood pressure, increase heart rate;
normalizes lipid metabolism
cause dyspeptic symptoms;
headache; hypotension.

Question 5

Drotaverine (no-shpa) and papaverine

Answer 5

Reduce the tone of the smooth muscles of blood vessels, including coronary, increasing the delivery of O2 to the myocardium and internal organs (colic);
Papaverine impairs myocardial conductivity.
Moderately reduce blood pressure;
are of secondary importance and are used to prevent attacks of stenocardia, chimes - for bicycle ergometric tests (for determining the functional reserve).

Question 6

Reflex vasodilators (validol)

Answer 6

It acts from the cold receptors of the oral cavity, reflexively expanding the coronary vessels;
The onset of action is 1 min, the duration of action is 10-15 min .;
take under the tongue in the form of a solution on a piece of sugar, capsules and tablets.
Ineffective! Used for the relief of attacks, in the early stages of coronary artery disease.
Reduces headache caused by the use of nitroglycerin.

Question 7

Stable analogues of prostacyclin

Answer 7

Ailoprost, carbacyclin
prostacyclin - a short-lived prostanoid (1.5 min), an endogenous regulator of vascular tone
dilate blood vessels
↓ platelet aggregation,
stabilize lysosome membranes (↓ necrosis).
Rarely used, place in the treatment of CHD is not defined