Activators of potassium channels

Question 1

Activators of potassium channels

Answer 1

they open K-channels, cause hyperpolarization of the membrane and ↓ entry of Ca into cardiomyocytes and vessels,
↓ heart rate and O2 consumption,
causes expansion of the coronary vessels and ↑ O2 delivery to the myocardium,
used for the prevention of strokes.

Question 2

K-channel activators

Answer 2

Minoxidil, Diazoxide, Nicorandil, pinocidil

Question 3

Drugs that reduce the need for heart O2

Answer 3

anaprilol, atenolol, metoprolol, nebivolol have anxiolytic effect;
have antiarrhythmic effect and antihypertensive effect; ↓ coronary blood flow, leveled ↓ diastolic voltage of the myocardium, shifting the oxyhemoglobin dissociation curve to the left.

Question 4

А2-adrenoreceptor blockade

Answer 4

increased tone of intact coronary vessels - redistribution of blood in favor of ischemic sites

Question 5

Activators of potassium channels drugs

Answer 5

Amiodarone

Question 6

Amiodarone

Answer 6

has antianginal, antiarrhythmic effect;
↓ heart work, their consumption of O2;
dilates coronary vessels, ↑ coronary blood flow.

Question 7

Amiodarone Side effects :

Answer 7

T1 / 2 - 10-50 days, remain long.
AV blockade, bradycardia, dyspepsia;
abnormal liver function, thyroid gland;
deposition of microcrystals in the cornea of ​​the eye; colors the skin blue-gray.

Question 8

Amiodarone Indications

Answer 8

prevention of CHD attacks

arrhythmias