Calcium channel blockers

Question 1

The mechanism of antianginal action of calcium channel blockers

Answer 1

↓ myocardial consumption of O2
↑ O2 myocardium delivery
accelerate repair processes after myocardial infarction;
have antiplatelet and anti-atherosclerotic effect.

Question 2

Side effects and complications calcium channel blockers

Answer 2

Hypotension with myocardial ischemia
Headache, dizziness; redness of the face
Swelling of the legs
Bradycardia, AV-blockade
Reflex tachycardia in response to a decrease in vascular tone
Constipation (often gives verapamil
Occasionally, heart failure 
-withdrawal syndrome

Question 3

Contraindications of calcium channel blockers

Answer 3

individual intolerance
cardiogenic shock;
-hypotension;
-bradycardia, HF, AV blockade (verapamil, diltiazem);
-the first week after myocardial infarction;
-subaortic stenosis;
-first trimester of pregnancy and lactation

Question 4

Difference calcium channel blockers from beta blockers

Answer 4

not addictive;
do not affect lipid, carbohydrate, urate metabolism
lower the tone of the bronchi; improve renal excretory function;
less influence on physical, mental, sexual activity, do not cause depression
CCB and Beta-Abl blend well with nitrates,
Beta-Abl is not recommended to be combined with verapamil.

Question 5

Slow Ca channel blockers (1)

Answer 5

dihydroperidin derivatives :
1st generation: Phenigidin,
2nd generation: amlodipine, isradipine, felodipine, nicardipine;

Question 6

Slow Ca channel blockers (2)

Answer 6

phenylalkylamine derivatives
1st generation: verapamil (isoptin)
2nd generation: gallopamil

Question 7

Slow Ca channel blockers (3)

Answer 7

benzothiazepine derivatives
1st generation: Diltiazem
2nd generation: Clentiazем