Pharmacokinetics

Question 1

For IV what is Bioavaliability (F)=?

Answer 1

1

Question 2

Vd increases if it has _________ protein binding?

Answer 2

decreased

Question 3

Vd is highest in?

Answer 3

Tissues including fat

Question 4

What is clearance?

Answer 4

Clearance=Rate of elimination of a drug/plasma drug conc.

Question 5

CL=?

Answer 5

Vd*K

Question 6

Half life is a property of?

Answer 6

1st order elmination

Question 7

Drug takes ________ to reach steady state?

Answer 7

4-5 half-lives

Question 8

It takes __________ half0lives to reach 90% steady state?

Answer 8

3.3

Question 9

Formula for Half life?

Answer 9

t1/2=(0.7*Vd)/CL

Question 10

Loading Dose=?

Answer 10

Loading Dose=Plasma conc. at peakVdweight/(bioavailiabilty)

Question 11

Maintenance Dose=?

Answer 11

Plasma conc. at peakCLdosage interval

Question 12

In renal or liver disease

Answer 12

maintenance dose=>decreased

Question 13

Time to steady state solely depends on

Answer 13

t1/2

Question 14

How do you treat weak bases like amphetamines?

Answer 14

Ammonium Chloride

Question 15

How do you treat weak acids like MTX, aspirin, TCA?

Answer 15

Bicarbonate

Question 16

In drug metabolism, geriatrics lose?

Answer 16

phase 1 first

Question 17

In drug metabolism, geriatrics still have?

Answer 17

GAS

Glucuronidation, Acetylation, Sulfation

Question 18

Safer drugs have?

Answer 18

Higher TI

Question 19

What are some Lower TI drugs?

Answer 19

Dig, lithium, theophylline and warfarin

Question 20

TITE?

Answer 20

Therapeutic Index=TD50/ED50