Pharmacokinetics

Question 1

Clearance (CL)

Answer 1

CL = Vd x Ke

Question 2

Css (Concentration at Steady-State)

Answer 2

1) Single dose:
Css = Ro / (Ke x Vd)

2) Multiple doses:
Css = Dm / (T x Ke x Vd), where
Dm is maintenance dose
T is Time between doses

3) Multiple Oral doses:
Css = (Dm x F) / (T x Ke x Vd), where
F is the bioavailability

Question 3

Concentration C(t) at time t 
(single IV dose)

Answer 3

C(t) = C(0) x e ^ (-Ke / t)