Anti fungals

Question 1

What is MOA of Amphotericin B?

Answer 1

Binds to Ergosterol in funcal cell membrane to make channels. Ion leakage. Cell death.

Question 2

How is Amp B given?

Answer 2

IV

Question 3

Amp B side effects?

Answer 3

Nephrotoxicity

Question 4

What is Nystatin? How is it taken?

Answer 4

A polyene, like Amp B. It is taken as a mouthwash (Thrush) or a suppository (vaginal candidiasis)

Question 5

What is the MOA of Azoles?

Answer 5

Inhibit ergosterol synthesis by inhibiting enzymes.

Question 6

What is the main side effect of Azoles?

Answer 6

Inhibits CYP 450. Hepatotoxicity.

Question 7

What Azole has good CNS penetration?

Answer 7

Fluconazole.

Question 8

How is itraconazole different from fluconazole?

Answer 8

Itraconazole is broader acting but has poor CNS penetration.

Question 9

What is voriconazole?

Answer 9

Even broader than itraconazole, but very expensive.

Question 10

Side effects of voriconazole?

Answer 10

Hallucinations.

Question 11

What is voriconazole used for?

Answer 11

Aspergillosis.

Question 12

What is MOA of echinocandins?

Answer 12

Inhibits glucan synthesis (a cell wall component).

Question 13

What is main use of echinocandins?

Answer 13

Candidiasis

Question 14

What is flucytosine and what does it treat?

Answer 14

Flucytosine is a chemotherapeutic agent. Treats cryptococcal meningitis with Amp. B

Question 15

What are some topical anti-fungal creams?

Answer 15

Allylamines (terbinafine)