Pharmacokinetics Flashcards
Which is not part of the stages of pharmacokinetics; Administration, absorption, distribution and metabolism?
Administration.
What is the main organ involved in metabolism?
The liver.
True or false, the liver, brain and kidneys can metabolise drugs?
True.
What factors affect drug metabolism?
Route of administration, age, and liver disease/impairment.
What is the main organ involved in drug excretion?
The kidneys.
What is the bioavailability of a drug?
The fraction of drug that reaches the bloodstream from site of administration.
What does half-life tell us about drugs?
An idea if how long the drug stays in the system.
What is a pro drug?
A drug that is activated through metabolism.
What are the routes of excretion for drugs?
Urination, exhalation, saliva, tears, breast milk.
What factors affect drug excretion?
Renal impairment, age, presence if other drugs.
What adverse drug reactions must you report?
Adr that cause: death, hospital admission or ongoing stay, adr in children.
Drug interactions can be…
Harmful or beneficial, pharmacokinetic or pharmacodynamic, with food herbals and addictive substances.
What are the stages of pharmacokinetics?
Absorption, distribution, metabolism and excretion.
