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Psychopharmacology > Pharmacokinetics > Flashcards

Pharmacokinetics Flashcards

1
Q

Best TCA for in the elderly

A

Lofepramine

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2
Q

What is the protein binding ratio of diazepam?

A

30-40%

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3
Q

What other name does meperidine go by

A

Pethidine

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4
Q

What is the half life of fluoxetine

A

2-3 days

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5
Q

Half life of norfluoxetine

A

2 weeks

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6
Q

Balanced hydrophobic and hydrophilic properties are essential for what quality in a drug

A

High permeability

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7
Q

Zaleplon half life

A

1 hour

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8
Q

Which antipsychotic will be most affected by the air

A

Sodium valproate

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9
Q

Half life of quetiapine

A

7 hours

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10
Q

Buspirone causes severe withdrawal effects, true or false

A

FALSE - causes none

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11
Q

What is the basis of clozapine induced hypersalivation?

A

Muscarinic M4 agonism

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12
Q

Poor response to lithium maintenance treatment is predicted by

A

Rapid cycling

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13
Q

Receptor blockade in which pathway leads to increased prolactin levels

A

Tuberoinfundibular

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14
Q

Weight gain caused by clozapine is due to

A

5Ht2c antagonism

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15
Q

Which antidementia drug acts directly on nicotine receptors

A

Galantamine

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16
Q

Mechanism of action of valproate

A

Inhibits catabolism of GABA
Reduces turnover of arachidonic acid
Activates EC signal related kinase pathway and thereby alters synaptic plasticity
Interfers with IC signalling
Promotes BDNTF expression
Reduces levels of protein kinase C

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17
Q

Buspirone acts on

A

5HT1a receptor

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18
Q

What % patients develop tardive dyskinesia every year of typical antipsychotics?

A

2-5%

19
Q

Is moclobemide reversible or irreversible

A

Reversible

20
Q

Carbamazepine, SJW, phenytoin and topiramate are inducers of what

A

CYP3A4

21
Q

What do gabapentin, sulpride, amisulpride and lithium have in common

A

Little to no hepatic metabolism

22
Q

What is the active component of SJW

A

Hyperforin

23
Q

In a patient with severe liver disease, the antipsychotic of choice is

A

Amisulpride

24
Q

The SSRI most selective for serotonin reuptake is

A

Citalopram

25
Q

Active metabolite of imipramine

A

Desipramine

26
Q

Urinary acidification can help with OD of what

A

Amphetamines

27
Q

Urinary alkalisation can help with OD of what

A

Salicylates

28
Q

Effect of smoking on TCAs

A

Facilitates metabolism, lowers levels 25-50%

29
Q

Effect of TCAs on their own absorption

A

May reduce own absorption (anticholinergic effects)

30
Q

TCA plasma protein binding

A

Extensive

31
Q

Which drug induces its own metabolism and reduces its plasma levels after 2 weeks at the same dose

A

Carbamazapine

32
Q

Effect of fluvoxamine on theophylline

A

Increases levels by inhibiting CYP1A2

33
Q

Clonidine and guanfacine act on which receptors

A

Presynaptic alpha 2 (agonists)

34
Q

Paroxetine autoinhibits via what

A

CYP 450 2D6

35
Q

When plotting plasma conc against time, AUC after a single dose shows

A

Bioavailability

36
Q

There is poor absorption of antipsychotics in which part of the GI tract

A

Stomach

37
Q

What is venlafaxine metabolised to

A

O desmethylvenlafaxine

38
Q

Half life of aripiprazole

A

75 hours

39
Q

Which treatment for mania can be commenced with a rapid loading dose?

A

Valproate

40
Q

How many weeks are needed between fluoxetine and phenelzine?

A

5-6

41
Q

The enhancement of drug effects following repeated administration of the same dose is called

A

Sensitisation

42
Q

Which benzos skip phase 1 reactions and go straight through phase 2 metabolism?

A

Lorazepam, oxazepam and temazepam

43
Q

Protein binding reactions become relevant in which condition?

A

Renal disease

Psychopharmacology (14 decks)

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