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Psychopharmacology > Pharmacodynamics > Flashcards

Pharmacodynamics Flashcards

1
Q

Which action causes anorgasmia

A

Alpha 1 antagonism

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2
Q

Blockade of postsynaptic D2/3 receptors in the limbic system does what

A

Reduces positive symptoms

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3
Q

What mood stabilisers are not licensed for acute mania?

A

Lamotrigine
Topiramate
Gabapentin

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4
Q

Citalopram and escitalopram are weak inhibitors of

A

CYP 1A2 and 2D6

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5
Q

SSRIs which are potent inhibitors

A

Fluoxetine
Fluvoxamine
Paroxetine

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6
Q

Which TCAs are more sedating?

A

Amitriptyline and dothiepin

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7
Q

What antipsychotic is best tolerated in PD?

A

Quetiapine

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8
Q

What should be avoided in PD?

A

Risperidone and typicals

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9
Q

What anticholinergic effect does aripiprazole have

A

none

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10
Q

Tyramine gains neuronal access and releases stored catecholamines via

A

Catecholamine reuptake channels

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11
Q

Which TCA has a stimulant effect and is best in ADHD?

A

Desipramine

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12
Q

Full agonist at mu receptor, long half life

A

Methadone

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13
Q

Chronic TCA use results in

A

Downregulation of beta adrenergic receptors

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14
Q

Mechanism of action of cyproheptadine

A

H1 blockade
Also 5HT2 antagonist

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15
Q

What side effects is cyproheptadine useful for treating

A

SSRI sexual SEs
Akathasia

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16
Q

What is california rocket fuel

A

Mirtazapine + SNRI (venla/dulox)

17
Q

Which street drug is a “dissociative anaesthetic”

18
Q

Which group of medication is most a/w bruxism?

A

stimulants

19
Q

Acamprosate mechanism of action

A

Glutamate antagonism

20
Q

Buspirone mechanism of action

A

5HT1A partial agonist

21
Q

What is the only antidepressant that can reasonably be used with an MAOI

A

Amitriptyline

22
Q

Barbituates mechanism of action

A

Increases duration of Chloride channel opening

23
Q

High D2/5HT2 activity

A

Risperidone

24
Q

Which SSRIs are used to treat premature ejaculation

A

Fluox and sertraline

25
Q

Disulfiram acts on

A

Aldehyde dehydrogenase

26
Q

Therapeutic effects of conventional antipsycotics is due to

A

Blockade of D2 receptors in the MESOLIMBIC PATHWAY

27
Q

Mechanism of action of trazodone

28
Q

Metabolite of trazodone (and action of this)

A

mCPP - 5HT2C agonist

29
Q

Endogenous substrates for MAO

A

Adrenaline, dopamine, serotonin

30
Q

Mechanism of action of varenicline

A

Partial nicotinic agonism

31
Q

Excitotoxicity from overstimulation with glutamate results in neuronal damage - this is the rationale for treating neurodegenerative disorders with

32
Q

Blockage of which receptor provides antidepressant effects

Psychopharmacology (14 decks)

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