Pharmacodynamics Flashcards
Which action causes anorgasmia
Alpha 1 antagonism
Blockade of postsynaptic D2/3 receptors in the limbic system does what
Reduces positive symptoms
What mood stabilisers are not licensed for acute mania?
Lamotrigine
Topiramate
Gabapentin
Citalopram and escitalopram are weak inhibitors of
CYP 1A2 and 2D6
SSRIs which are potent inhibitors
Fluoxetine
Fluvoxamine
Paroxetine
Which TCAs are more sedating?
Amitriptyline and dothiepin
What antipsychotic is best tolerated in PD?
Quetiapine
What should be avoided in PD?
Risperidone and typicals
What anticholinergic effect does aripiprazole have
none
Tyramine gains neuronal access and releases stored catecholamines via
Catecholamine reuptake channels
Which TCA has a stimulant effect and is best in ADHD?
Desipramine
Full agonist at mu receptor, long half life
Methadone
Chronic TCA use results in
Downregulation of beta adrenergic receptors
Mechanism of action of cyproheptadine
H1 blockade
Also 5HT2 antagonist
What side effects is cyproheptadine useful for treating
SSRI sexual SEs
Akathasia
What is california rocket fuel
Mirtazapine + SNRI (venla/dulox)
Which street drug is a “dissociative anaesthetic”
Ketamine
Which group of medication is most a/w bruxism?
stimulants
Acamprosate mechanism of action
Glutamate antagonism
Buspirone mechanism of action
5HT1A partial agonist
What is the only antidepressant that can reasonably be used with an MAOI
Amitriptyline
Barbituates mechanism of action
Increases duration of Chloride channel opening
High D2/5HT2 activity
Risperidone
Which SSRIs are used to treat premature ejaculation
Fluox and sertraline
