Adverse Effects Flashcards
Which sex is more at risk of QTc prolongation?
Female
Commonest side effect of methylphenidate
Insomnia
What drug is helpful for treating SEs from reboxetine
Doxazosin
What % tardive dyskinesia cases are reversible with dose reduction?
50-55%
SSRi most a/w erectile dysfunction
Paroxetine
Agranulocytosis occurs most commonly during the first how many weeks of Rx
18
Worst class of antideps for weight gain
TCAs
Which receptor type is involved in hypersalivation with clozapine use
Muscarinic
Anticholinergics are helpful for which SE
Dystonia
Most commonly a/w priapism
Trazodone
Which benzo is worst in OD
Alprazolam
Principle cause of death in TCA OD is
Cardiac arrhythmia
Principle cause of death in TCA OD is
Cardiac arrhythmia
Sexual SEs with SSRIs are due to what receptor
5HT2
Which diuretic can help with lithium induced polyuria without causing toxicity?
Amiloride
Patients on clozapine/olanzapine should have lipids checked how often for the 1st year?
3 monthly
Most common adverse effect of valproate
Diarrhoea
What is the treatment for cheese+MAOI induced hypertension?
Phentolamine
Lithium induced hypothyroidism is most common in
Young females
Which drug is a/w nephrolithiasis
Topiramate
Risk of fatal agranulocytosis in clozapine patients
1/4250
Which receptor is reponsible for drug induced weight gain
5HT2C
Bupropion effect on weight
Weight loss
Anxiety and agitation in the first few weeks of SSRIs are due to what
Overstimulation of 5HT2 receptors in limbic system
What happens to the plasma levels of both TCAs and APsys if co-administered
Both increase
Which SSRI is most expressed in breast milk
Fluoxetine
Sweating due to venlafaxine can be treated with what
Alpha-adrenergic blocker Terazosin
Postural hypotension due to TCAs is caused by
Alpha adrenergic blockade
TCA with most antihistaminergic activity
Doxepin
ABx that can cause serotonin syndrome if combined with MAOi
Linezolid
Confusional state caused by antipsychotics is due to
Muscarinic blockade
SE of mianserin requiring monitoring
Bone marrow suppression
Botox can be helpful to treat
Tardive Dystonia
Tardive dystonia occurs after
Months to years of treatment
Which type of antipsychotic has a lower risk of TD?
Atypicals
Which antidepressant is contraindicated in closed angle glaucoma
Paroxetine
Floppy baby syndrome a/w
Benzos
In treating serotonin syndrome, antagonism of which receptor is helpful for controlling neuro symptoms?
5HT2A
