Pharmacokinetics Flashcards
What order does pharmacokinetics go in ?
- Route of administrations
- Distrubution
- Metabolism
- Exertion
What are the different types of route of administration?
- Oral administration
- Rectal administration
- Dermis injection
- intramuscular injections
- intravengenous
- Topical agents
7.Buccal administration
8.Sublingual administration
How does positive diffusion help drugs get to the blood?
Small, hydrophobic drugs use positive diffusion to get pass the gastrintestal linig through the cell membrane.
So the drugs goes through the cell membrane of the basal lateral to the blood.
How does facilitated diffusion help the drugs get to the blood through the cell membrane?
A large hydrophilic drug uses the faciliated diffusion to het through the cell membrane though protein transporters helping it make it through to the blood.
How does active transport help the drugs get to the blood through the cell memebrane?
A large hydrophilic drugs goes to the blood through the process of active transport, which requires ATP (energy) to get through. This goes from low to high concentration.
How does endocytosis help thr drugs get to the blood through the cell memebrane?
Very large drugs such as B12 are too big so they use bulk transports, the drug binds with the little receptors of the cell memebrane which will trigger the drug to move through the memebrane into the blood.
Which route of administration does not need to go through cell membranes?
intravengenous (IV) injects as the needle goes directly to the veins.
What are the factors affecting absorption?
PH and blood flow.
How does weak acid drugs get absorbed?
Weak acid drugs are absorbed when they are present in a acidic area e.g promixal duodenum in the stomach.
How are weak base drugs absorbed?
Weak base drugs are more absorbed in alkaline areas .e.g the illuem in the small intestine.
How does blood flow have an affect on absorption?
If the blood flow is decreased e.g when a patient is in shock , it will decrease the flow of blood to the organs in the system which will cause the drugs to be less absorbent.
