Drug targets

Question 1

What are ligand ion channels?

Answer 1

1. The drug binds to the pockets of the gates
2. Which opens the gates allowing ions in and out of the cell

Question 2

What is g protein process?

Answer 2

1.The drug binds to the recpetor domain which changes the shape
2.It stimulis the Gs which will get rid of gdp and use gtp
3.The gtp will activate the aclenylate cyclase enzymes in the cell membrane
4.The enzymes will then be activated, so it takes ATP and converts it to cyclic amp
5.The cyclic amp protein kinase
6.The protein kinase adds phosphate on the protein channels which allow the cell membrane to open and close the ion channels

Question 3

How does tyserol kinase receptors work?

Answer 3

1. The drug (Insulin) bind to the receptor
2. One binded it will activiate the tyserol receptors and tyserol residue the phostphate will cross over
3. Which will change the structure allows phosphate to bind to proteins or the 2nd messenger
4. This will activate the cyclic amp which will activate protein kinase
5. Resulting in cellular response

Question 4

How does the intracellular receptors work?

Answer 4

1. small hydrophobic, non-polar drugs e.g steriods are small enough to get into the cell memebrane
2. Which will then bind to the intracellular receptors which will translocate to the nucleus binding to the transcription factors DNA –> RNA into proteins
3. Resulting in cellular response

Question 5

How many transmembranes does g proteins have?

Answer 5

7 transmembranes

Question 6

How many types of G protein are there and what are the names?

Answer 6

3
Gi
Gs
Gq

Question 7

What is GTP and what bind to it ?

Answer 7

Alpha which is a g protein subunit binds to Guanosine triphosphate