Pharmacokinetics

Question 1

What affects distribution of drugs?

Answer 1

Blood absorption
ease of penetration
retention of the drug within tissues

Question 2

Things that stop penetration of drug?

Answer 2

Blood-brain barrier, blood retinal barrier and blood placental barrier

Question 3

explain the 1st pass elimination

Answer 3

When administered orally, 1st pass elimination occurs as the drug is metabolised by the liver and gut which reduces the general dosage in the body.

Question 4

sites of administration of drugs

Answer 4

Orally, IV, topically, Intramuscular, subcutaneous, rectally, vginally, inhalation, buccal, intranasal.

Question 5

Describe elimination of drugs

Answer 5

Elimination of the drug can be done through multiple routes. Mainly the kidney then drug is passed through urine. Other routes include; breath, saliva, sweat, breast milk.

Question 6

how are drugs distributed into the body and tissues?

Answer 6

Distribution refers to the drug being passed from bloodstream to surrounding tissues. depending on the solubility of a drug will depend on where it is distributed. A water soluble drug will distribute to other sites compared to a fat soluble drug.
Fat soluble drugs typically cross membranes quicker than water soluble.
Drugs penetrate different tissues at different speeds, depending on the drug’s ability to cross membranes.