PHARMACOKINETICS 1 Flashcards
A KEY DETERMINANT OF THE EFFECTIVENESS AND USEFULNESS OF A DRUG DEPENDS ON ACHIEVING THE CORRECT ………..
CONCENTRATION
WHAT ARE THE THINGS THAT AFFECT DRUG CONCENTRATION
MECHANISM OF ACTION OF THE DRUG
THE DRUG TARGET
THE PHYSICOCHEMICAL PROPERTIES OF THE DRUG
BODILY PROCESSES
WHAT BODILY PROCESS AFFECTING DRUG CONC
ABSORPTION
DRISTRIBUTION
METABOLISM
EXCRETION
WHAT CAN BE SAID ABOUT THE CONCENTRATION OF A DRUG THROUGHOUT THE BODY
THE CONCENTRATION WILL REACH A CONSTANT BUT THIS CONSTANT WILL BE DIFFERENT ACROSS BODILY COMPARTMENTS
WHAT DIFFERENT BODY COMPARTMENTS ARE THERE
PLASMA ISF LYMPH FAT IC FLUID TRANSCELLULAR FLUID
HOW DO DRUGS MOVE BETWEEN COMPARTMENTS
VIA BARRIERS
HOW CAN DRUGS MOVE ACROSS BARRIERS
DIFFUSION THROUGH THE BILAYER
DIFFUSION THROUGH CHANNELS
CARRIERS
PINOCYTOSIS
WHAT IS THE PARTITION CO-EFFICIENT
THIS IS A MEASURE OF LIPID SOLUBILITY
IE THE HIGHER THE CO-EFFICIENT THE MORE EASILY DIFFUSIBLE IN LIPIDS
NON POLAR MOLECULES DISSOLVE ………………… IN LIPIDS AND PENETRATE CELL ……………………… FREELY. THIS MEASURE THAT THERE IS AN ………………….. RATE OF GUT ABSORPTION AS WELL AS PENETRATION INTO BRAIN AND TISSUES AS WELL AS ……………………… EXRETION.
FREELY
MEMBRANES
INCREASED
RENAL
DIFFUSION IS ……………………. TO THE SIZE OF THE DRUG
PROPORTIONAL
WHAT ARE THE ROUTES OF ADMINISTRATION
ORAL/RECTAL PERCUTANEOUS INTRAVENOUS INTRAMUSCULAR INTRATHECAL INHALATION
WHAT IS THE FASTEST ROUTE OF ADMINISTRATION
INTRAVENOUS
WHERE IS THE MORE COMMON SITE OF ADMINISTRATION FOR BIOLOGICS AND WHY
INTRAMUSCULAR
TO ESCAPE METABOLISM
WHAT IS INTRATHECAL
DIRECTLY IN CSF
WHAT IS BIOAVAILABILITY
FREE CONC OF DRUG IN PLASMA/THE AMOUNT OF DRUG TAKEN
