ANTI INFLAMMATORIES 1

Question 1

WHAT DOES NSAID STAND FOR

Answer 1

NON STEROIDAL ANTI INFLAMMATORY DRUGS

Question 2

IF YOU HAVE PRE EXISTING HEART ISSUES, IS IT WISE TO TAKE NSAIDS WITHOUT CONSULTING A DR

Answer 2

NO

Question 3

WHAT IS THE HISTORY OF ASPIRIN

Answer 3

ORIGINALLY SALICYCLIC ACID FROM THE WHITE WILLOW BUT HAD MANY UNDESIRABLE EFFECTS
WAS THE FIRST SYNTHESISED DRUG IN ITS CONVERSION TO ACETYL SALICYLIC ACID WHICH WE NOW KNOW AS ASPIRIN

Question 4

HOW DOES ASPIRIN WORK

Answer 4

IS A SUICIDE INHIBITOR THEREFORE BINDS TO CYCLOOXYGENASE ON THE SERINE RESIDUE
THIS MEANS THE TIME COURSE FOR ASPIRIN IN THE TIME IS TAKES FOR THE BODY TO MAKE NEW COX ENZYMES

Question 5

WHAT ARE THE PROPERTIES OF NSAIDS

Answer 5

ANTI -INFLAMMATORY
ANALGESIC (REDUCES SOME TYPES OF PAIN)
ANTIPYRETIC (REDUCES TEMPERATURE)

Question 6

WHAT ARE THE BEST KNOWN NSAIDS

Answer 6

ASPIRIN
IBUPROFEN
PARACETAMOL

Question 7

HOW DOES IBUPROFEN WORK

Answer 7

COMPETITIVE INHIBITOR

Question 8

WHAT CHARACTERISTIC DOES PARACETAMOL NOT HAVE

Answer 8

PARACETAMOL IS NOT ANTI INFLAMMATORY PURELY BECAUSE IT ACTS ON THE CENTRAL NERVOUS SYSTEM

Question 9

WHAT IS THE AIM OF NSAIDS

Answer 9

DECREASE THE PRODUCT OF INFLAMMATORY MEDIATORS SUCH EICOSANOIDS

Question 10

WHAT ARE EICOSANOIDS

Answer 10

SIGNALLING MOLECULES DERIVED BY THE OXYGENATION OF ARACHIDONIC ACID

Question 11

WHAT CLASSES OF EICOSANOIDS ARE THERE

Answer 11

PROSTAGLANDINS, LEUKOTRINES AND THROMBOXANES

Question 12

WHAT CONVERTS PHOSPHOLIPID TO ARACHIDONATE

Answer 12

PHOSPHOLIPASE

Question 13

WHAT ARE PROSTAGLANDINS

Answer 13

PARACARINE MEDIATORS INDUCED BY TISSUE DAMAGE THAT DIFFUSE OUT AND ACT ON SURROUNDING CELLS AND THEIR RECEPTORS (GPCR)

Question 14

WHAT DO PROSTAGLANDINS STIMULATE

Answer 14

CHEMOATTRACT OTHER INFLAMMATORY CELLS
INCREASE SENSITIVITY OF NOCICEPTORS
CONSTRICTION OF SMOOTH MUSCLE
PLATELET AGGREGATION
THIS DEPENDS ON WHAT PROSTAGLANDINS IN WHAT TISSUE

Question 15

ARACHINDONATE IS THEN CONVERTED TO WHAT

Answer 15

CYCLIC ENDO PEROXIDES

Question 16

WHAT DO CYCLIC ENDOPEROXIDES CONVERT TO

Answer 16

PROSTAGLANDINS

Question 17

HOW IS ARACHINDONATE CONVERTED TO CYCLIC ENDOPEROXIDES

Answer 17

BY CYCLOOXYGENASE

Question 18

HOW DO NSAIDS WORK

Answer 18

NSAIDS INHIBIT COX ENZYMES THEREBY PREVENTING RELEASE OF INFLAMMATORY MEDIATORS

Question 19

WHAT COX ENZYMES ARE THERE

Answer 19

COX1
COX2
COX3

Question 20

WHERE IS COX1 FOUND

Answer 20

IN ALL CELL AND IS ALWAYS ACTIVE (IMPORTANT IN HOMEOSTASIS)

Question 21

WHERE IS COX2 FOUND

Answer 21

FOUND IN INFLAMMATORY CELLS AND IS INDUCED

Question 22

WHERE IS COX3 FOUND

Answer 22

IS A SPLICE VARIANT OF COX1 AND IS RESTRICTED TO THE CNS

Question 23

WHY IS COX1 NOT THE BEST TARGET

Answer 23

IMPORTANT IN HOMEOSTASIS THEREFORE MAY HAVE SIDE EFFECTS

Question 24

WHAT IS THE MOST COMMON SIDE EFFECT OF NSAIDS

Answer 24

GUT ISSUES: DYSPEPSIA, DIARRHOEA, NAUSEA, ULCERS

Question 25

WHY DO NSAIDS HAVE SIDE EFFECTS ON THE GUT

Answer 25

PROSTAGLANDINS HOMEOSTATICALLY HAVE A ROLE IN ACID SECRETION AND PROTECTION OF THE MUCOSA

Question 26

WHY DO NSAIDS ALSO AFFECT THE KIDNEYS

Answer 26

PROSTAGLANDINS HOMEOSTATICALLY HAVE A ROLE IN RENAL BLOOD FLOW THEREFORE THERE IS A CHANCE OF RENAL FAILURE

Question 27

WHAT OTHER ISSUES DO NSAIDS CAUSE

Answer 27

LIVER DAMAGE | PARACETAMOL HAS A TOXIC INTERMEDIATE

Question 28

SOME NSAIDS ARE ADVANTAGEOUS FOR OTHER ISSUES LIKE

Answer 28

ASPIRIN IS AN ANTI THROMBOTIC FOR COX 1 AND IN SMALL DOSES CAN BE USED TO PREVENT HEART ATTACK/ STROKE