ANTI INFLAMMATORIES 1 Flashcards
WHAT DOES NSAID STAND FOR
NON STEROIDAL ANTI INFLAMMATORY DRUGS
IF YOU HAVE PRE EXISTING HEART ISSUES, IS IT WISE TO TAKE NSAIDS WITHOUT CONSULTING A DR
NO
WHAT IS THE HISTORY OF ASPIRIN
ORIGINALLY SALICYCLIC ACID FROM THE WHITE WILLOW BUT HAD MANY UNDESIRABLE EFFECTS
WAS THE FIRST SYNTHESISED DRUG IN ITS CONVERSION TO ACETYL SALICYLIC ACID WHICH WE NOW KNOW AS ASPIRIN
HOW DOES ASPIRIN WORK
IS A SUICIDE INHIBITOR THEREFORE BINDS TO CYCLOOXYGENASE ON THE SERINE RESIDUE
THIS MEANS THE TIME COURSE FOR ASPIRIN IN THE TIME IS TAKES FOR THE BODY TO MAKE NEW COX ENZYMES
WHAT ARE THE PROPERTIES OF NSAIDS
ANTI -INFLAMMATORY
ANALGESIC (REDUCES SOME TYPES OF PAIN)
ANTIPYRETIC (REDUCES TEMPERATURE)
WHAT ARE THE BEST KNOWN NSAIDS
ASPIRIN
IBUPROFEN
PARACETAMOL
HOW DOES IBUPROFEN WORK
COMPETITIVE INHIBITOR
WHAT CHARACTERISTIC DOES PARACETAMOL NOT HAVE
PARACETAMOL IS NOT ANTI INFLAMMATORY PURELY BECAUSE IT ACTS ON THE CENTRAL NERVOUS SYSTEM
WHAT IS THE AIM OF NSAIDS
DECREASE THE PRODUCT OF INFLAMMATORY MEDIATORS SUCH EICOSANOIDS
WHAT ARE EICOSANOIDS
SIGNALLING MOLECULES DERIVED BY THE OXYGENATION OF ARACHIDONIC ACID
WHAT CLASSES OF EICOSANOIDS ARE THERE
PROSTAGLANDINS, LEUKOTRINES AND THROMBOXANES
WHAT CONVERTS PHOSPHOLIPID TO ARACHIDONATE
PHOSPHOLIPASE
WHAT ARE PROSTAGLANDINS
PARACARINE MEDIATORS INDUCED BY TISSUE DAMAGE THAT DIFFUSE OUT AND ACT ON SURROUNDING CELLS AND THEIR RECEPTORS (GPCR)
WHAT DO PROSTAGLANDINS STIMULATE
CHEMOATTRACT OTHER INFLAMMATORY CELLS INCREASE SENSITIVITY OF NOCICEPTORS CONSTRICTION OF SMOOTH MUSCLE PLATELET AGGREGATION THIS DEPENDS ON WHAT PROSTAGLANDINS IN WHAT TISSUE
ARACHINDONATE IS THEN CONVERTED TO WHAT
CYCLIC ENDO PEROXIDES