Pharmacogenomics Flashcards
0
Q
Trastuzumab (herceptin) and ado-Trastuzumab (kadcyla)
A
Her2/neu oncogene needed for response
1
Q
Carbamazepine
A
HLA-B*1502 expression puts the patient at 5 to 10% chance of having a severe skin reaction (SJS)
More common in Asians
2
Q
Warfarin
A
2c92 and 2c93 and VKORC1 if increased
Increased risk of bleeding
Decrease dose
3
Q
Maraviroc (selzentry)
A
Tropism testing
If CCR5 + ONLY can give drug
