Pharmacogenetics and IRF-5

Question 1

what is IRF

Answer 1

inteferon regulating factors, DNA binding protein regulating transcription of inteferon genes

Question 2

IRF-5 is responsible for what defences

Answer 2

1. inflammatory
2. antiviral
3. modulate cell growth/differentiation/apoptosis/immune system activity/apoptosis
4. link to autoimmune diseases

Question 3

where are IRFs expressed

Answer 3

within B cells, macrophages and dendritic cells

Question 4

why express IRF

Answer 4

viral infection
TLR-dependent signaling DNA damage that translocates to nucleus

Question 5

mechanism of IRF-5

Answer 5

binds to MyD88 and positively regulate TLR-dependent induction of proinflammatory cytokines to induce inteferon

Question 6

IRF-5 polymorphism is caused by

Answer 6

single nucleotide substitution