Pain management

Question 1

what is a common nocireceptor mutation

Answer 1

nerve growth factor TrkA receptor

Question 2

nerve growth factor TrkA receptor mutation leads to

Answer 2

no nocireceptor, therefore congenital pain hyposensitivity

Question 3

Nav1.7 mutation with SCN9A leads to

Answer 3

inactive gene, hence unable to code for voltage-gated sodium channel Nav1.7 and unable to feel pain

Question 4

Nav1.7 mutation with SCN9A leads to

Answer 4

inactive gene, hence unable to code for voltage-gated sodium channel Nav1.7 and unable to feel pain