Gene drug interactions leading to hypersensitivity

Question 1

Steven Johnson Syndrome/toxin epidermal necrolysis is characterised by

Answer 1

erythema multiforme with extensive erosion lesions of skin and mucous membrances and purulent conjunctivitis, as well as corneal damage leading to blindness.

Question 2

carbamazepine induced cADR is due to which allele

Answer 2

HLA-B*15:02

Question 3

phenytoin-induced cADR is due to which allele

Answer 3

CYP2C9*3

Question 4

drug adverse reactions are classified as

Answer 4

type 4 hypersensitivity

Question 5

hapten theory in ADRs

Answer 5

drug binds to endogenous peptide where antigenic hapten-carrier complex resulting in reactive metabolite/drug becoming immunogenic. will form covalent bonds and induce drug specific immune responses.