Pharmacogenesis Flashcards
1
Q
What is L41 mutation
A
The GRK5 L41 mutation causes the GRK5 to internalize the GPCR protein more rapidly.
2
Q
What happens when these patients take beta blockers
A
There is not as much of a difference as patients with the normal allele in the heart simulation
People with L41 have “built in” beta blocker
3
Q
In which ethnicity is this mutation common
A
African American