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Pharmacology 1 > Pharmacodynamics - Receptors > Flashcards

Pharmacodynamics - Receptors Flashcards

1
Q

what is drug action

A

initial consequences of drug-target combination

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2
Q

what is the effect of the binding of an appropriate ligand to a receptor

A

regulatory signal sent to target cell

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3
Q

what type of responses can be seen from the binding of a ligand to a receptor

A

physiological or pharmacological

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4
Q

what is an example of an endogenous neurotransmitter

A

hormones

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5
Q

what type of ligand is a drug

A

exogenous

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6
Q

what are exogenous ligands

A

those that are introduced into the body

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7
Q

what is the weakest chemical force

A

Van der Waals

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8
Q

what is the most common bond with drugs/receptors that is irreversible

A

covalent bonds

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9
Q

what is the “hierarchy” of bond strength

A

covalent > ionic > hydrogen > Van der Waals

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10
Q

what type of receptor has unknown ligands

A

orphan receptors

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11
Q

what type of receptors are regulated by agonists

A

ionotropic receptors

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12
Q

what is an example of an ionotropic receptor

A

ligand gated ion channel

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13
Q

what type of receptor affects the metabolic process within the cell

A

metabotropic

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14
Q

what are the types of receptors?

A
  1. ligand-gated
  2. G protein coupled receptors
  3. Protein Tyrosine Kinase
  4. Intracellular Receptors
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15
Q

which receptor mediates the response of insulin and growth factors

A

Protein Tyrosine Kinase

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16
Q

what receptor is activated by hormone groups IN A CELL

A

intracellular receptors

17
Q

what receptor only opens when the receptor is occupied by an agonist

A

ligand gated ion channel

18
Q

what receptor has the quickest response time

A

ligand gated ion channel

19
Q

what receptors are regulated by adenylyl cyclase, phospholipase C, and Ca+/K+ channels

A

G-Protein Coupled Receptors

20
Q

what halts the activity of a GPCR

A

hydrolysis of the GTP to GDP

21
Q

what type of response can a GPCR induce

A

stimulatory or inhibitory

22
Q

what is the purpose of the G alpha-s protein

A

increase adenylyl cyclase
increase cAMP

23
Q

what is the purpose of the G alpha-s protein

A

increase adenylyl cyclase
increase cAMP

24
Q

what is the purpose of G alpha-i

A

decrease adenylyl cyclase
decrease cAMP

25
Q

what is the purpose of the G alpha-q protein

A

increase phospholipase C
increase pKa activity

26
Q

where are the intracellular receptors found in the cell

A

cytoplasm

27
Q

what is the result of the intracellular receptors being activated

A

increase binding of RNA polymerase

28
Q

what is the effect of ligand-gated ion channels

A

depolarization/ hyperpolarization

Pharmacology 1 (10 decks)

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