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Y1 - HPP2 > Pharmacodynamics IV > Flashcards

Pharmacodynamics IV Flashcards

1
Q

How are drugs classified?

A

Classification, Nomenclature

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2
Q

What do we classify drugs in terms of?

A

Body systems, Therapeutics (receptor blockers, ion channels), Site of action (cellular site)

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3
Q

Describe the chain of effects

A

Molecular pharmacology (drug receptor interaction), Cell pharmacology, Cell physiology, Tissue physiology (tissue function alterations), Organ physiology, Clinical effect (illness treated)

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4
Q

Briefly describe what happens during an asthma attack

A

Airways/vessels become constricted/narrower

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5
Q

Describe contraindications

A

Salbutamol acts on sympathetic control (dilation of bronchi)
B2 agonists cause fight/flight effect on rest of system
B blockers used to treat forms of heart disease (B1 blockers for asthmatics with heart disease)

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6
Q

Describe antihypersensitive products

A

B-blockers, A-blockers, Diuretics (forced urine), Angiotensin converting enzyme inhibitors, Ca channel blockers, Vasodilators, Drugs affecting CNS control of bp

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7
Q

Describe the function of angiotensin converting enzyme inhibitors (ACE)

A

Peptide hormones causes vasoconstriction/inc bp, stimulates release aldosterone

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8
Q

Describe multiple molecular actions

A

ACE inhibitors/Cardiac failure - Blocks formation of angiotenisin II (blocks vasocontriction/aldosterone preventing water retention)
and Blocks bradykinin breakdown (leads to vasodilation)

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9
Q

Describe the hormones released the autonomic nervous system (ANS)

A

SNS - Release Nora/Adrenaline

PSN - Release Acetylcholine

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10
Q

Describe ACh

A

Agonist on PSNS, acts on both muscarinic/nicotinic receptors

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11
Q

Describe muscarinic receptors

A

They’re G-protein coupled , causes smooth muscle cell contraction, endothelial cell stimulation and initiation of vasodilation
Slowing of heart rate and conductance

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12
Q

Describe nicotinic receptors

A

They’re ligand-gated Na channels causing muscle contraction and neuronal excitation

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13
Q

What are the different types of drug receptors?

A

Adrenoreceptors, Histamine, Serotinin, muscarinic, opioid

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14
Q

Describe adrenoreceptors

A

Epinephrine - Increase cardiac output

Propranolol - B-blockers used for hypertension

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15
Q

Describe histamine

A

Cimetidine H2 receptor - Inhibits stomach acid production

H1 receptor - Treat allergies

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16
Q

Describe muscarinic receptors

A

Atropine - Anticholinergic, treats bradycardiac, induce eye dilation

17
Q

Describe opioid receptors

A

Morphine - Analgesic drug

Y1 - HPP2 (17 decks)

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