Pharmacodynamics

Question 1

Pharmacodynamics

Answer 1

study of the action of drugs on the body

Question 2

which type of G protein activates adenyl cyclase which catalyses atp to camp which then influences a protein kinase to bring about cellular events

Answer 2

s

Question 3

which type of G protein inhibits adenylate cyclase and has negative effect on cAMP and PKA

Answer 3

I

Question 4

which type of G protein activates phospholipase c - this enzyme catalyses conversion of PIP2 to DAG and IP3 and these inflecue PKC and IP3 which is a calcium regulator.

Answer 4

Q

Question 5

Agonist drugs do what

Answer 5

activate receptors, switch them on

Question 6

Antagonist drugs do what

Answer 6

block receptors, often inhibit endogenous agonist action - these can then cause biological effects

Question 7

what are the two stages of agonist drugs

Answer 7

Drug binding affinity is stage 1
Receptor activation efficacy is stage 2 - brings about a biological response or change ie could increase heart rate for example

Question 8

efficacy

Answer 8

Efficacy - how well it brings back a response

Question 9

what is agonist drug potency

Answer 9

product of affinity and efficacy ( the way the tissue responds is how well it binds to receptors and how well it can bind to the receptor)

Question 10

Antagonists don’t activate receptors so have 0 efficacy ( ability to produce intended result)
Still cause effect, when they block receptors see a reduction in endogenous activity. what do they do

Answer 10

inhibit receptors