pharmacodynamics Flashcards
1
Q
morphine
A
agonist
–>efficacy
2
Q
pentazocine
A
partial agonist ( the efficacy(max) is not as hight) -->lower efficacy
3
Q
naloxane
A
antagonist
no effect
–>zero efficacy
4
Q
nelmefene
A
inverse agonist
important= reduces basal activity of receptor
thus makes more inactive drug then active
Ex: alcohol overdose
–>negative efficacy
5
Q
naloxene
A
competitive antagonist Binding reversible Decreased potency The same efficacy Parallel shift to the right
treat overdose of opioids
6
Q
ketamine
A
non-competitive antagonist Binding irreversible Decreased efficacy The same potency Downward displacement
7
Q
Allosteric Modulation
A
Bind a site on the receptor distinct from the active site changing the affinity of the receptor for the ligand
can be inhibiting (ketamine) or activating benzodiazepine)
8
Q
therapeutic index
A
radio of
toxic dose/effective dose
