drug-drug

Question 1

penicillin + tetracycline

Answer 1

Antagonism

Effect of A is reduced or even diminished by B

Question 2

succinylcholine + neostigmine

Answer 2

Potentiation

Effect of A is greater with presence of B; A and B have different MOA

Question 3

morphine + meperidine

Answer 3

Summation

Combined effect of A and B is the sum of their individual effect; A and B have identical or similar MOA

Question 4

cocktail treatment for AIDS

Answer 4

Synergism

Combined effect of A and B is greater than the sum of their individual effect; A and B have different MOA

Question 5

tetracycline+iron

Answer 5

antagonist

prevent absorbtion

Question 6

digoxin+quinidine

Answer 6

potentiation

Question 7

metaprolol+nitroglycerin

Answer 7

synergism

Question 8

aspirin+walfarin

Answer 8

synergism

Question 9

toxicity

Answer 9

target organ
predictable n dose-related
hypoglycemia caused by insulin

Question 10

side effect

Answer 10

non - target organ
Predictable and dose-related
muscle wasting caused by Lipitor

Question 11

Idiosyncratic Reaction

Answer 11

Genetically determined abnormal response
Normally involves a change in enzyme activity
Unpredictable and dose-related
Example: response to codeine in patients that are either poor or ultra-rapid metabolizers

Question 12

allergy

Answer 12

Abnormal reaction of your immune system to a medication
Can be mild or severe, even life threatening
Unpredictable and not dose-related
Example: anaphylaxis caused by penicillin

Question 13

estrogen therapy

Answer 13

carcinogenic

Question 14

thalidomide

Answer 14

teratogenic

Question 15

Pure Food and Drug Act

Answer 15

1906 -

Forbade the adulteration and mislabeling of drugs

Question 16

Harrison Narcotic Act

Answer 16

1914 -

Regulated opioids and cocaine

Question 17

Durham-Humphrey Act

Answer 17

1952 -

Used restriction for certain drugs by Rx only

Question 18

Food, Drug, and Cosmetic Act

Answer 18

1938 -

Mandated safety and the role of FDA in enforcing it