anti-parkinson

Question 1

Carbidopa

Answer 1

anti-parkinson
can not cross BBB:
prevents peripheral conversion of L-DOPA into dopamine
more Carbidopa ⇢ moreL-DOPA delivered into the CNS
Side effects: hallucinations, dizziness, headache, nausea and vomiting, arrhythmias, and dyskinesia

Question 2

L-DOPA

Answer 2

anti-parkinson

can cross the BBB and is converted into dopamine in the CNS

Question 3

Pramipexole, ropinirole

Answer 3

anti-parkinson
non-ergot

Side effects: drowsiness, nausea, vomiting, dry mouth, dizziness, leg swelling, and orthostatic hypotension

Impulse control disorders: gambling, shopping, binge eating, and sexual behavior (overactive DA signaling)

Question 4

Selegiline

Answer 4

anti-parkinson

Monoamine oxidase type B (MAO-B) inhibitor

Question 5

tolcapone

Answer 5

anti-parkinson
Catechol-O-methyltransferase (COMT) inhibitor
(peripheral and central)

Question 6

amandamine

Answer 6

anti-parkinson
MAO: increase DA release, 
decrease DA re-uptake
side effects: ataxia, livedo rebicularis
used in treating Neuroleptic melignant syndrome when taking antipsychotic drugs

Question 7

Benzotropine

Answer 7

anti-parkinson
M1 antagonist
decrease Ach signaling, increase DA release by inhibing the reuptake