Pharmacodynamics

Question 1

Noncovalent bonds from strongest to weakest

Answer 1

Ionic
Hydrogen
Hydrophobic interactions
Van der waals

Question 2

How is therapeutic index calculated

Answer 2

TD50/ED50

The higher the TI the safer the drug

Question 3

What parameter describes the affinity of a drug for its receptor

Answer 3

KD = equilibrium dissociation constant

Question 4

Property of a drug determined by its affinities at various binding sites — measured by comparing affinities of a drug to different receptors

Answer 4

Selectivity

Question 5

Compare agonists to antagonists - which one has intrinsic activity?

Answer 5

Agonists have intrinsic activity

Question 6

How does a competitive antagonist affect the dose response curve in terms of EC50 and Emax?

Answer 6

Agonist EC50 increases

Emax does not change

Question 7

How does a noncompetitive antagonist affect the dose response curve in terms of EC50 and Emax?

Answer 7

Agonist Emax decreases

EC50 does not change

Question 8

How does Emax relate to efficacy of drug?

Answer 8

The greater the Emax, the more efficacious the drug