pharmacodynamics Flashcards
agents that act on specific enzymes
Asprin, methotrexate, tranylcypromine, nitroglycerin, heparin, imitinib, infliximab
Asprin
acts on specific enzymes. inhibits cyclooxygenase
methotrexate
acts on specific enzymes. inhibits dihydrofolate reductase. antineoplastic (cancer)
tranylcypromine
acts on specific enzymes. inhibits monoamine oxidase. antidepressent.
nitroglycerin
acts on specific enzymes. activates guanylate cycline. for treating angina
heparin
acts on specific enzymes. activates antithrombin. antigoagulant
imitinib
acts on specific enzymes. inactivates a protein kinase. leukemia
infliximab
acts on specific enzymes. binds to TNF. arthritis
agents that act on trasport systems
cocaine, chlorothiazide, fluoextine, omeprazole
cocaine
acts on transport. nhibits norepinephrine reuptake by neuron
chlorothiazide
acts on transport. diuretic, blocks inhibits transport of Na and Cl by kidney tubule
fluoxetine
acts on transport. inhibits serotonin reuptake by neurons. antidepressent
omeprazole
acts on transport. inhibits H transport by parietal cells. decreases stomach acid.
agents that act on ion channels
nifedipine, minoxidil, procaine
nifedipine
acnts on ion channels. Ca channl blocker. antihypertensive
minoxidil
acts on ion channels. increases K uptake by cells. antihypertensive
procaine
acts on ion channels. local anesthetic. inhibits Na channels
agents that act on cell membrane receptors
propranolol, cimetidine, prazosin, morphine .insulin
propranolol
acts on cell membrane. blocks beta adrenergic receptor. antihypertensive.
cimetidine
acts on cell membrane. blocks histamine receptors. decreases stomach acid
prazosin
acts on cell membrane. blocks alpha 1 receptors in blood vessels. antihypertensive
morphine
acts on cell membrane. activates opiate receptors. pain
insulin
acts on cell membrane. activates insulin receptor. diabetes.
agents that act on intracellular receptors
steroids. glucocorticoids, cortisol (anti-inflammatory)
