autonomic drugs

Question 1

Direct acting cholinergi agonists, muscarinic

Answer 1

muscarine, piocarpine, bethanechol

Question 2

Direct acting chol agonists. nicotinic

Answer 2

nicotine, succinylcholine

Question 3

direct acting chol agonists. partial nicotinic agonists

Answer 3

varenicline

Question 4

indirect acting chol. agonists

Answer 4

physostigmine, neostigmine, demecarium, edrophonium, echothipophate, donepezil, tacrine

Question 5

how do indirect acting chol agonists work

Answer 5

all of them inhibit AChE to prolong the effect of ACH

Question 6

which indirect chol agonists have lon lasting effects

Answer 6

physostigmine, neostigmine, demecarium

Question 7

which indirect chol agonist has a short effect

Answer 7

edrophonium

Question 8

what is echothiophate used for

Answer 8

glycoma, myasthenia gravis, sgogren’s syndrome, is phosphorylates AChE and can inhibit hundreds of hours. also affects choleno receptors of muscles

Question 9

which indirect chol antagonists treat alzheumer’s

Answer 9

donepezil, tacrine

Question 10

what does pralidoxime do

Answer 10

if given early, can revearse any permanent damage caused by organophosphate AChE inhibitors

Question 11

what are irreversibel AChE inhibitors

Answer 11

Malathion (insecticide) Sarin (nerve gas)

Question 12

Antimuscarinic agents

Answer 12

atropine, scopolamine, ipratropium

Question 13

atropine

Answer 13

antimuscarinic agent, it blocks a lot of DUMBBELS effect if given soon after exposer, lasts 7-10 days

Question 14

scopolamine

Answer 14

antimuscarinic agent, blocks dumbbels lasts 3-7 days. used to treat motion sickness

Question 15

ipratropium

Answer 15

antimuscarinic agent. used in asthma

Question 16

derifenicin

Answer 16

used to treat urinary incontinece

Question 17

tiotropium

Answer 17

asthma

Question 18

antinicotinic agents

Answer 18

succinycholine, pancuronium, atracurium, rocuronium, sugammadex

Question 19

succinylcholine

Answer 19

depolarizing antinicotinic agent. long duration, intially activates receptor, eventually there is muscle hyperpolarization lead to paralysis (used in surgery)

Question 20

non depolarizing antinicotinic agents

Answer 20

pancuronium, atracurium, rocuronium, skeletal muscle ACh receptor blockers, all derived from curare

Question 21

sugammadex

Answer 21

non depolarizing antinicotinic agent, reverses blockade by rocuronium by binding it directly

Question 22

botulinum toxin type A

Answer 22

antinicotinic agent, inhibitor of ACh release, muscle paralytic agent. used cosmetically, treats muscle spasms…tics, strabismus, nystagmus

Question 23

epinephrine

Answer 23

adrenergic agonist, acts on all adregergic receptors (alpha and beta)

Question 24

agents that activate alpha 1 receptor

Answer 24

phenylephrine, tetrahydrozoline, naphazoline

Question 25

pheylephrine

Answer 25

adrenergic agonist, activates alpha 1 receptor, decreases intranasal congestion

Question 26

tetrahydrozoline

Answer 26

adrenergic agonist, activatesalpha 1 receptor, decreases intranasal congestion

Question 27

naphazoline

Answer 27

adrenergic agonist, activates alpha 1 receptor, decreases intranasal congestion

Question 28

agents that activate alpha 2 receptors

Answer 28

clonidine, alpha methyl norepinephrine

Question 29

clonidine

Answer 29

adrenergic agonist, alpha 2, decrease symp. outflow from CNS. used to treat hypertension

Question 30

alpha methyl norepinephrine

Answer 30

adrenergic agonist, alpha 2. decrease symp. outflow from CNS, used to treat hypertension.

Question 31

agents that activate beta 1 receptor

Answer 31

norepinephrine, dobutamine

Question 32

agents that activate beta 2 receptors

Answer 32

metaproterenol, terbutaline, fenoterol, aluterol. bronchodilation for treating asthma

Question 33

indirect acting amines, which induce the release of NE from nerve terminals

Answer 33

amphetamine, methamphetamine, tyramine, pheylpropanolamine, pseudo-ephedrine

Question 34

amphetamine/methamphetamine

Answer 34

indirect acting amines, which induce the release of NE from nerve terminals

Question 35

tyramine

Answer 35

indirecting acting amines, which inuce the release of NE from nerve terminals

Question 36

phenylpropanolamine

Answer 36

indirect acting amines, which induce the release of NE from nerve terminals

Question 37

pseudoephedrine

Answer 37

indirect acting amines, which induce the release of NE from nerve terminals

Question 38

adrenergic antagonists - alpha 1 blocker

Answer 38

prazosin, pheoxybenzyamine

Question 39

prazosin

Answer 39

adrenergic antagonist, alpha 1 blocker, antihypertensive

Question 40

phenoxybenzyamine

Answer 40

adrenergic antagonist alpha 1 blocker

Question 41

phetolamine

Answer 41

adrenergive antagonist, alpha 1 and 2 receptor blocker

Question 42

tolazoline

Answer 42

adrenergic antagonist, alpha 2 blocker

Question 43

metoprolol

Answer 43

specific beta 1 blocke, decrease HR

Question 44

acebutolol

Answer 44

specific beta 1 blocker, decrease HR

Question 45

alprenolol

Answer 45

specific beta 1 blocker, decrease HR

Question 46

atenolol

Answer 46

specific beta 1 blocker, decrease HR

Question 47

esmolol

Answer 47

specific beta 1 blocker, decrease HR

Question 48

propranolol

Answer 48

non specific beta 1 and 2 blocker

Question 49

timolol

Answer 49

non specific beta 1 and 2 blocker

Question 50

levobuolol

Answer 50

non specific beta 1 and 2 blocker

Question 51

carteolol

Answer 51

non specific beta 1 and 2 blocker

Question 52

metipranolol

Answer 52

non specific beta 1 and 2 blocker