PHARMACODYNAMICS

Question 1

the cellular macromolecule or macromolecular complex
with which the drug interacts to elicit a cellular or systemic
response

Answer 1

Receptors/Drug Targets

Question 2

Receptors mediate the ——- of
pharmacologic agonists and antagonists. And receptors are responsible for —– of drug actions

Answer 2

actions (affinity and efficacy) and selectivity (specificity)

Question 2

the central focus of investigation of drug effects and their
mechanisms of action

Answer 2

Receptors/Drug Targets

Question 3

Receptors largely determine the quantitative relations
between (P & E)

Answer 3

dose or concentration (POTENCY) of drug and
pharmacologic EFFECTS.

Question 4

ability to bind to receptors

Answer 4

Affinity

Question 6

tissue response is proportional to number of receptors occupied (affinity)

Answer 6

Occupancy Theory

Question 7

Drug receptor interaction

Question 8

Drug receptor interaction effect is proportional to rate of drug

Answer 8

Rate Theory

Answer 9

Induced Fit Theory