DRUGS WITH ANTICHOLINERGIC ACTIONS

Question 1

Motion Sickness Drug
MOA: unknown in CNS

C/A: Prevention of motion sickness and post operative nausea and vomiting

Answer 1

Scopolamine

Question 2

Gastrointestinal Disorder
MOA: competitive antagonist at M3 receptors

C/A: Irritable bowel syndrome, minor diarrhea

Answer 2

Dicyclomine

Question 3

Ophthalmology

MOA: Competitive antagonism at all M receptors

C/A: Retinal examination; prevention of synechiae after surgery

Answer 3

Atropine

Question 4

Ophthalmology
Shorter duration of action (12-24 h) than atropine

Answer 4

Homatropine

Question 5

Ophthalmology
Shorter duration of action (3-6 h)

Answer 5

Cyclopentolate:

Question 6

Ophthalmology
Shortest duration of action (15-60 min)

Answer 6

Tropicamide

Question 7

Respiratory(Asthma/COPD)

MOA: Competitive, nonselective antagonist at M receptors

C/A: Prevention and relief of acute episodes of bronchospasm

Answer 7

Ipratropium

Question 8

•Respiratory (Asthma/COPD)
Longer duration of action; used once daily ( TAU )

Answer 8

Tiotropium, aclidinium, and umecidinium:

Question 9

MOA: Slightly M3-selective muscarinic antagonist

C/A: Urge incontinence; postoperative spasms

Answer 9

Oxybutynin

Question 10

Cholinergic poisoning
MOA: Very high affinity for phosphorus atom but does not enter CNS
C/A: Usual antidote for early-stage (48 h) cholinesterase inhibitor poisoning

Answer 10

Pralidoximine