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PHARM 200 Lecture Midterm > Pharmaceutical Dosage Forms > Flashcards

Pharmaceutical Dosage Forms Flashcards

1
Q

Preparations containing the active ingredient

A

pharmaceutical dosage forms

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2
Q

Reasons for formulating dosage forms

A

Stability
Improved solubility
Improved appearance
Ease of administration
Palatability

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3
Q

Major types of dosage forms

A

Liquid dosage forms
Solid dosage forms

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4
Q

Term: Sublingual
Site:

A

Under the tongue

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5
Q

Term: Oral
Site:

A

Mouth (GI Tract via mouth)

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6
Q

Term: Epicutaneous
Site:

A

Skin surface

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7
Q

Term: Conjunctival
Site:

A

Conjunctiva

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7
Q

Term: Transdermal
Site:

A

Skin surface

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8
Q

Term: Intraocular
Site:

A

Eye

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9
Q

Term: Intranasal
Site:

A

Nose

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10
Q

Term: Rectal
Site:

A

Rectum

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10
Q

Term: Aural (otic)
Site:

A

Ear

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11
Q

Term: Vaginal
Site:

A

Vagina

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12
Q

Term: Parenteral
Site:

A

Other than the GI Tract (by injection)

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13
Q

Term: Intravenous
Site:

A

Vein

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13
Q

Term: Intracardiac
Site:

A

Heart

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14
Q

Term: Intra-arterial
Site:

A

Artery

14
Q

Term: Intraspinal or intrathecal
Site:

A

Spine

14
Q

Term: Intraosseus
Site:

A

Bone

15
Q

Term: Intra-articular
Site:

A

Joint

16
Q

Term: Intrasynovial
Site:

A

Joint fluid area

16
Q

Term: Intracutaneous, intradermal
Site:

A

Skin

16
Q

Term: Subcutaneous
Site:

A

Beneath the skin

16
Q

Term: Intramuscular
Site:

A

Muscle

16
Q

Preparation of Liquid Dosage Forms

A
  1. Dissolving the active ingredient in a suitable solvent
  2. Suspending the active ingredient in a suitable medium
  3. Incorporating the drug into the dual phase system
17
Q

Reasons for Formulating Liquid Dosage Forms

A

Improved solubility/absorption
For different routes of administration
For ease of administration

18
Q

Types of instability

A
  1. Chemical Instability
  2. Microbial Contamination
19
Q

Chemical Instability

A

a. Incompatibility with ingredients
b. incompatibility with container
c. hydrolysis
d. oxidation

19
Q

the movement of components of a container into the contents

A

leaching

20
Q

remedy for oxidation

A

addition of antioxidants or chelating agents (for trace metals)

20
Q

microbial contamination

A

a. raw material
b. equipment
c. personnel
d. packaging material

20
Q

the binding of molecules of the contents to the container

A

sorption

21
Q

remedy for microbial contamination

A

addition of preservatives depending on the spectrum of activity

22
Q

very soluble

A

< 1

23
Q

freely soluble

A

1-10

24
Q

sparingly soluble

A

30-100

24
Q

soluble

A

10-30

25
Q

slightly soluble

A

100-1000

26
Q

very slightly soluble

A

1000-10,000

27
Q

practically insoluble

A

> 10,000

PHARM 200 Lecture Midterm (5 decks)

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