Pharma : Cardiac Drugs (mostly) Flashcards
Antiarhythmic Drugs : Prototype Group IB
Lidocaine
Antiarhythmic Drugs : Prototype Group IC
Flecainide
Antiarhythmic Drugs : Prototype Group 2
Propranolol and Esmolol
Antiarhythmic Drugs : Prototype Group 3
Dofetilide and Ibutilide
Antiarhythmic Drugs : Prototype Group 4
Verapamil
Anticonvulsant sometimes classified as group 1b because it can reverse diitalis-induced arrhythmias
Phenytoin
Amiodarone is a group 3 antiarrhythmic but can also be classified as…
Group 1A
This drug has the greatest action potential prolonging block. (Which ion curren is it blocking?)
Amiodarone
Potassium
This drug when given with digoxin will increase serum concentration of digoxin?
Quinidine
Quinidine, drug that prolongs AP duration, is associated with what new arryhthmia?
Torsades de pointes
Which drug is most likely to precipitate arrhythmias? (Proarrhythmic effect)
Flecainide
Group 1c
Antiarrhythmic drug group used to reduce progression of heart failure and as prophylaxis from new onset arrhythmias post MI?
Group 2
B Blockers
Antiarrhythmic drug which blocks spdium, calcium, and potassium channels and B adrenoceptors?
Amiodarone
Drug of choice for abolishing av nodal arrhythmias?
Adenosine
Nonselective B blockers
Propranolol and timolol
B1 selective B blockers
Atenolol, acebutolol, metoprolol
Possibly leas hazardous in asthmatic patients
B blockera with partial agonist effect
Acebutolol and pindolol
B blocker which lacks lical anesthetic effect
Timolol
B blocker with low lipid solubilty
Atenolol
Shortest acting b blocker
Esmolol
Longest acting b blocker
Nadolol
B blocker with combined a blockade
Carvedilol, labetolol
Antiarhythmic Drugs : Prototype Group IA
Procainamide
Antiarrhythmic with logest half life
Amiodarone
Which antiarrhythmic drug can cause sle like symptoms?
Procainamide
Which antiarrhythmic drug has cinchonism (headache, vertigo, tinnitus) as toxicity?
Quinidine
Most suitable therapy for acute arrrhthymia in patient with thyrotoxicosis?
Esmolol (b blockers)
Procainamide toxicity antidote
Sodium lactate
Which antiarrhythmic drug is useful in digoxin-induced arrhythmias and acute MI arrhythmias?
Lidocaine
On ECG, prolonged PR interval, qrs and qt interval is caused by…
Group 1a
Prolonged pr interval and qt interval is caused by
Sotalol (group 3)
Cholesterol gallstones may be a side effect of these lipid lowerig agents except Cholysteramine Clofibrate Bezafibrate Gemfibrozil Ezetimibe
Ezetimibe
What drug inhibits lipolysis in adipose tissu consequently reducing. Hepatic VLDL in curculation?
Niacin
Most effective to decrease LDL
HMG-CoA reductase inhibitors (statins)
Most effecive to reduce triglycerides
Fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate)
MOA of fibrates in lipid lowering
Upregulating lipoprotein lipase
Statins inhibit which cholesterol precursor
Mevalonate
Site of action of ezetimibe
Small intestine brush border
Drugs you could use to control BP in pheochromocytoma
Phenoxybenzamine, phentolamine, labetalol
Tx for rebound hypertension caused by clonidine
Phentolamine
Antidote to cyanide poisoning
Inhaled amyl nitrite + IV sodium nitrite + IV sodium thiosulfate
Cyanide affects what portion ETC?
Complex IV (cytochrome oxidase)
Cholesterol gallstones may be a side effect of these lipid lowerig agents except Cholysteramine Clofibrate Bezafibrate Gemfibrozil Ezetimibe
Ezetimibe
What drug inhibits lipolysis in adipose tissu consequently reducing. Hepatic VLDL in curculation?
Niacin
Most effective to decrease LDL
HMG-CoA reductase inhibitors (statins)
Most effecive to reduce triglycerides
Fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate)
MOA of fibrates in lipid lowering
Upregulating lipoprotein lipase
Statins inhibit which cholesterol precursor
Mevalonate
Site of action of ezetimibe
Small intestine brush border
Drugs you could use to control BP in pheochromocytoma
Phenoxybenzamine, phentolamine, labetalol
Tx for rebound hypertension caused by clonidine
Phentolamine
Cholesterol gallstones may be a side effect of these lipid lowerig agents except Cholysteramine Clofibrate Bezafibrate Gemfibrozil Ezetimibe
Ezetimibe
What drug inhibits lipolysis in adipose tissu consequently reducing. Hepatic VLDL in curculation?
Niacin
Most effective to decrease LDL
HMG-CoA reductase inhibitors (statins)
Most effecive to reduce triglycerides
Fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate)
MOA of fibrates in lipid lowering
Upregulating lipoprotein lipase
Statins inhibit which cholesterol precursor
Mevalonate
Site of action of ezetimibe
Small intestine brush border
Drugs you could use to control BP in pheochromocytoma
Phenoxybenzamine, phentolamine, labetalol
Tx for rebound hypertension caused by clonidine
Phentolamine
Cholesterol gallstones may be a side effect of these lipid lowerig agents except Cholysteramine Clofibrate Bezafibrate Gemfibrozil Ezetimibe
Ezetimibe
What drug inhibits lipolysis in adipose tissu consequently reducing. Hepatic VLDL in curculation?
Niacin
Most effective to decrease LDL
HMG-CoA reductase inhibitors (statins)
Most effecive to reduce triglycerides
Fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate)
MOA of fibrates in lipid lowering
Upregulating lipoprotein lipase
Statins inhibit which cholesterol precursor
Mevalonate
Site of action of ezetimibe
Small intestine brush border