Pharma- Antivirals

Question 1

guanosine analog
for HSV, VZV
needs activation to Acyclovir Triphosphate

Answer 1

Acyclovir

Question 2

Resistant Strains of HSV to Acyclovir lacks_

Answer 2

Thymidine Kinase

Question 3

TK- Strains of HSV cross resistant to

Answer 3

Famciclovir
Ganciclovir
Valacyclovir

Question 4

Oral Acyclovir for

IV for

Answer 4

Mucocutaneous and Genital Herpes
Prophylaxis in AIDS patients

Severe Herpes- enceph
Neonatal HSV

Question 5

Drug for HSV and VZV that does not cause chain termination

Answer 5

Penciclovir

Question 6

Aliphatic Alcohol that inhibits fusion between HSV envelope and plasma membrane
Prevents viral entry

Answer 6

Docosanol

Question 7

Guanine derivative

Answer 7

Ganciclovir

Question 8

Inhibits DNA POL of CMV and Hsv

Answer 8

Ganciclovir

Question 9

T/F

TK- strains of HSV are also resistant to Ganciclovir

Answer 9

True

Question 10

CMV retinitis

Answer 10

Intraocular implant of Ganciclovir

Question 11

Oral form with High oral bioavailability taht decreased IV form use of Ganciclovir

Answer 11

Valganciclovir

Question 12

Ganciclovir causes severe neutropenia when used with

Answer 12

ZIDOVUDINE

Question 13

Active against ACYCLOVIR AND GANCICLOVIR RESISTANT STRAINS

Answer 13

Cidofovir

Question 14

for HPV(warts), CMV, ADenovirus, HSV

Answer 14

Cidofovir

Question 15

Antivirals that does not require phosphorylation for activation

FOfo does not need phosphorylation

Answer 15

foscarnet

CidoFOvir

Question 16

For Ganciclovir resistant CMV

For Acyclovir resistant Herpes

Answer 16

Foscarnet

Question 17

Used topically for Herpes Keratitis

Answer 17

Vidarabine

Question 18

Antisense nucleotide that binds to mRNA of CMV

Injected intraVITREALLY to tx CMV retinitis

Answer 18

Fomivirsen