Pharma-antihepa

Question 1

T/F

Goal for treating infections caused by HBV is to cure disease.

Answer 1

F

Suppress

Question 2

T/F

Primary goal in HCV tx is Suppress the disease

Answer 2

F

Eradicate

Question 3

Cytokine that acts by increasing activity of JAKS-> increasing formation of antiviral proteins

Answer 3

IFN-a

Also promotes NK cells formation

Question 4

used for CHRONIC HBV

Answer 4

IFN-a

Lamivudine

Question 5

____ IFN-a with____ offers better effectivity

oin CHRONIC HCV

Answer 5

Pegylated; Ribavirin

Question 6

Competitively inhibits HBV DNA pol

Suppress HBV replication with improvement of liver histology and fibrosis

Answer 6

Adefovir

Question 7

Toxicity that is dose limiting for adefovir

Answer 7

Nephrotoxicity

Question 8

Ribavirin effective against

RIPHH(ab)irin

Answer 8

R
Influenza A and B
Paramxyxo
HCV
HIV

Question 9

Lamivudine has longer intracellular half life with HBV infected cells than _____ infected Cells

Answer 9

HIV

thus lower dose for hepa than for HIV infection

Question 10

T/F

Lamivudine can be used as a monotherapy

Answer 10

True.

With rapid suppression of HBVreplication and non toxic

Question 11

For Chronic HCV with compensated liver disease

Answer 11

Ribavirin + IFN-a

Question 12

T/F

Monotherapy with Ribavirin is effective

Answer 12

F

Question 13

Early IV administration of this drug reduces mortality in VIRAL HEMORRHAGIC FEVERS

Answer 13

Ribaviring

Question 14

Active against Lamivudine and Entecavir resistant strains

Answer 14

Tenofovir

Question 15

Inhibits RNA Pol in HCV

Answer 15

Sofosbuvir

Question 16

PI in HCV used in combination with Ribavirin

Answer 16

Boceprevir