Pharm Unit 1: chapters 4,5

Question 1

what is pharmacokinetics

Answer 1

study of drug movement throughout the body

Question 2

what is pharmacogenetics?

Answer 2

study of genetic variations that influence a person’s response to drug therapy.

Question 3

the amount of drug required to produce a therapeutic effect

Answer 3

minimum effective concentration

Question 4

amount of time it takes to produce a therapeutic effect after drug administration

Answer 4

onset of drug action

Question 5

amount of time a drug maintains its therapeutic effect

Answer 5

duration of drug action

Question 6

length of time required for the plasma concentration of a med to decrease by one-half after administration

Answer 6

plasma half life

Question 7

higher amount of drug, often given onlyonce or twise to prime the bloodstream with a sufficient level of the drug.

Answer 7

loading dose

Question 8

doses given to keep the drug concentration in the therapeutic range

Answer 8

maintence doses

Question 9

what is pharmacodynamics

Answer 9

how a medicine changes the body.

Question 10

the dose required to produce a specific therapeutic response in 50% of a group of patients

Answer 10

ED50

Question 11

the dose of drug that will be lethal in 50% of a group of animals

Answer 11

LD50

Question 12

how does one figure out the therapeutic index?

Answer 12

median lethal dose LD50/median effective dose ED50

Question 13

the dose that will produce a given toxicity in 50% of a group of patients

Answer 13

median toxicity dose (TD50)

Question 14

what are the two fundamental ways to compare meds within the therapeutic and pharmacological classes?

Answer 14

understanding potency & efficacy…. drug that is more potent produces therapeutic effect at a lower dose.

Question 15

the magnitude of maximal response that can be produced from a particular drug

Answer 15

efficacy

Question 16

a drug that produces the same tpye of response as the endogenous substance is called

Answer 16

agonist

Question 17

medication that produces a weaker, or less efficacious, response than an agonist.

Answer 17

partial agonist/ agonist-antagonist drug

Question 18

when a drug occupies a receptor and prevents the endogenous chemical from acting

Answer 18

antagonist

Question 19

drug reactions that occur rarely and unpredictably amongst the population.

Answer 19

idiosyncratic response