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STEP 1 (5) > Pharm- Toxicities and Side Effects > Flashcards

Pharm- Toxicities and Side Effects Flashcards

1
Q

What is the antidote for Acetaminophin OD?

A

N-acetylcysteine (replenishes glutathione)

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2
Q

What is the antidote for AChE inhibitor, organophosphates OD?

A

Atropine > pralidoxime

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3
Q

What is the antidote for Amephetamines (basic) OD?

A

NH4Cl to acidify urine to trap it

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4
Q

What is the antidote for Antimuscarinic, anticholinergic OD?

A

Physostigmine salicylate, control hyperthermia

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5
Q

What is the antidote for Benzo OD?

A

Flumazenil

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6
Q

What is the antidote for BB OD?

A

Glucagon

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7
Q

What is the antidote for copper, arsenic, gold OD?

A

Penicillamine

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8
Q

What is the antidote for Cyanide OD?

A

Nitrate + thiosulfate, hydroxocobalamin

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9
Q

What is the antidote for heparin OD?

A

Protamine sulfate

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10
Q

What is the antidote for iron OD?

A

Deferoxamine or Deferasirox

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11
Q

What is the antidote for Lead OD?

A

EDTA, dimercaprol, succimer, penicillamine

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12
Q

What is the antidote for Mercury OD?

A

Dimercaprol (BAL), succimer

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13
Q

What is the antidote for Methemoglobin OD?

A

Methylene blue, vitC

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14
Q

What is the antidote for Opiods OD?

A

Naloxone, naltrexone

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15
Q

What is the antidote for Salicyclate OD?

A

NaHCO3 (alkalinize urine), dialysis

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16
Q

What is the antidote for tpA, streptokinase, urokinase OD?

A

Aminocaproic acid

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17
Q

What is the antidote for Warfarin OD?

A

vit K or fresh frozen plasma (faster)

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18
Q

What drugs can produce hot flashes as an AE?

A

Tamoxifen and Clomiphene

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19
Q

What drugs can produce hyperglycemia as an AE?

A

Tacrolimus, protease inhibitors, niacin, HCTZ, steroids

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20
Q

What drugs can produce hypothyroidism as an AE?

A

Lithium, amiodarone, sulfonamides

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21
Q

What drugs can produce acute cholestatic hepatitis, jaundice as an AE?

A

Erythromycin

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22
Q

What drugs can produce diarrhea as an AE?

A

Metofrmin, erythromycin, colchicine, orlistatm and acarbose

Might Excite Colon on Accident

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23
Q

What drugs can produce focal to massive hepatic necrosis as an AE?

A

Halothane, Amanita phalloides (death cap mushrooms), Valproic acid acetaminophen

Liver “HAVAc”

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24
Q

What drugs can produce hepatitis as an AE?

A

Rifampin, isoniazid, pyrazinamide, statins, and fibrates

25
Q

What drugs can produce pancreatitis as an AE?

A

Didanosine, steroids, alcohol, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

26
Q

What drugs can produce pseudomembranous colitis as an AE?

A

Clinamycine, ampicillin, cephalosporins

27
Q

What drugs can produce agrnaulocytosis as an AE?

A

ganciclovir, clozapine, carbamazepine, colchicine, methimazole, propthiouracil

28
Q

What drugs can produce asplastic anemia as an AE?

A

Carbamazepine, methimazole, NSAIDs, Benzene, chloramphenicol, and propylthiouracil

29
Q

What drugs can produce a driect coombs positive test as an AE?

A

Methyldopa and pencillin

30
Q

What drugs can produce grey baby syndrome as an AE?

A

Chloramphenicol

31
Q

What drugs can produce hemolysis in G6PD deficiency as an AE?

A

Isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

32
Q

What drugs can produce megaloblastic anemia as an AE?

A

Phenyotin, Methotrexate, sulfa drugs

33
Q

What drugs can produce thrombocytopenia as an AE?

34
Q

What drugs can produce thrombotic issues as an AE?

A

OCPs, and hormone replacement therapy

35
Q

What drugs can produce fat redistribution as an AE?

A

Protease inhbitors and steroids

Fat PIG

36
Q

What drugs can produce gingival hyperplasia as an AE?

A

Phenytoin, CCBs, Cyclosporine

37
Q

What drugs can produce hyperuricemia as an AE?

A

Pyrazinamide, Thiazides, Furosemide, Niacin, and Cyclosporine

Painful Tophi and Feet Need Care

38
Q

What drugs can produce myopathy as an AE?

A

Fibrates, niacin, colchicine,

hydroxychloroquine

interferon-a

perincillamine

statins

steroids

39
Q

What drugs can produce osteoporosis as an AE?

A

Steroids and heparin

40
Q

What drugs can produce photosensitivity as an AE?

A

Sulfonamides, amiodarone, tetracyclines, and 5-FU

SAT For Photo

41
Q

What drugs can produce SJS/TEN as an AE?

A

Anti-epileptic durgs (esp. lamitrigine), allopurinol, sulfa drugs, penicillin

42
Q

What drugs can produce a SLE like syndrome as an AE?

A

Sulfa drug, hydralazine, isoniazid, procainamide, phenyotin, etanercept

43
Q

What drugs can produce tendon rupture as an AE?

A

Fluroquinolones

44
Q

What drugs can produce cinchonism (Cinchonism or quinism is a pathological condition caused by an overdose of quinine or quinidine) as an AE?

A

Quinidine or quinine

45
Q

What drugs can produce Parkinson-like syndrome as an AE?

A

Antipsychoics, Reserpine, Metoclopramide

46
Q

What drugs can produce seizures as an AE?

A

Isoniazid, Bupropion (esp. with eating disorder), Imipenem, Enflurane

47
Q

What drugs can produce tardive dyskinesia as an AE?

A

Antipsychotcs, metoclopramide

48
Q

What drugs can produce diabetes inspidius as an AE?

A

Lithium or demeclocycline

49
Q

What drugs can produce Fanconi syndrome as an AE?

A

Expired tetracycline

50
Q

What drugs can produce hemorrhagic cystitis as an AE?

A

Cyclophsophamide or ifosfamide (prevent with mesna)

51
Q

What drugs can produce interstitial nephritis as an AE?

A

Methicillin, NSAIDS, and furosemide

52
Q

What drugs can produce SIADH as an AE?

A

Carbamazepine, Cyclophosphamide, SSRIs

53
Q

What drugs can produce dry cough as an AE?

54
Q

What drugs can produce pulmonary fibrosis as an AE?

A

Bleomycin, Amiodarone, Busulfan, Methotrexate

55
Q

What are the CYP inducers?

A

Chronic alcohol use

St. Johns Wort

Phenytoin, Phenobarbital, Carbamazepinr

Nevirapine

Griseofulvin

56
Q

What are the CYP inhbitors?

A

Acute alcohol use

Ritonavir

Amiodarone

cimetidine

ketoconazole

Sulfonamides

Grapefruit juice

Quinidine

Macroplides except azithromycin

57
Q

What are the sulfa drugs?

A

Probenecid

Furosemide, Thiazides

Acetazolamide

Celecoxib

Sulfonamide ABX

Sulfasalazine

Sulonylureas

58
Q

pts with sulfa allergies may present with:

A

Fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria

STEP 1 (5) (11 decks)

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