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STEP 1 (5) > Immunology-Pharmacology > Flashcards

Immunology-Pharmacology Flashcards

1
Q

What is Cyclosporine?

A

A calcineurin inhibitors that binds cyclophilin and blocks T cell activation by preventing IL-2 transcription for use in transplant rejection prophylaxis, psoriasis, and rheumatoid arthritis

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2
Q

What are the AEs of cyclosporine?

A

Nephrotoxicity (highly), HTN

hyperlipidemia

neurotoxicity

gingival hyperplasia

hirsutism

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3
Q

What is tacrolimus (FK506)?

A

a calcinueron inhibitor that binds Fk506 binding protein (FKBP) and blocks T cell activation by preventing IL-2 transcription mainly for use as a transplant rejection prophylatic

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4
Q

What are the AEs of Tacrolimus?

A

Similar to cyclosporine but with additional increased risk of diabetes and neutrotoxicity

no ginigival hyperplasia or hirsutism

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5
Q

What is Sirolimus (Rapamycin)?

A

an mTOR inhibitor that binds FKBP and blocks T cell activation and B cell differentiation by preventing the response to IL-2 for primary use as a kidney transplant rejection prophylatic (synergistic with cyclosporine)

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6
Q

What are the main AEs of Sirolimus (Rapamycin)?

A

Anemia, thrombocytopenia, leukopenia,

insulin resistance

hyperlipidemia

NOT NEPHROTOXIC

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7
Q

What is Daclizumab and Basiliximab?

A

MABs that bind to and block IL-2R for kidney transplant rejection prophylaxis

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8
Q

What are the main AEs of Daclizumab and Basiliximab?

A

Edema, HTN, and tremor

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9
Q

What is Azathioprine?

A

Antimetabolite precursor for 6-MP that inhibits lymphocyte proliferation for use in transplant rejection and autoimmune diseases

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10
Q

What are the main AEs of Azathioprine?

A

Leukopenia, anemia, and thrombocytopenia

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11
Q

6-MP is broken down by ______

A

xanthine oxidase so increased toxicity with allopurinol

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12
Q

How do glucocorticoids work?

A

Inhibit NF-kB to suppress both B and T cell function by decreasing transcription of many cytokines

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13
Q

What are some AEs of glucocorticoids?

A

Hyperglycemia

osteoporosis

central obesity/Iatrogenic Cushing syndrome

muscle breakdown

psychosis

acne

HTN
cataracts

avascular necrosis

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14
Q

What are the main uses of Aldesleukin (recombinant IL-2)?

A

renal cell carcinoma, melanoma METS

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15
Q

What are the main uses of Epoietin Alfa (recombinant EPO)?

A

Anemias (esp. in renal failure)

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16
Q

What are the main uses of Filgrastim (recombinant G-CSF)?

A

Recovery of bone marrow

17
Q

What are the main uses of Sargamostim (recombinant GM-CSF)?

A

Recovery of bone marrow

18
Q

What are the main uses of IFN-a?

A

chronic hep B and C, Kaposi, and melanoma METS

19
Q

What are the main uses of IFN-B?

A

MS

20
Q

What are the main uses of IFN-y?

A

CGD

21
Q

What are the main uses of romiplostim and eltrombopag?

A

Thrombocytopenia

22
Q

What are the main uses of Oprevlvekin (recombinant IL-11)?

A

Thrombocytopenia

23
Q

What is the target of Alentuzumab and what are its main uses?

A

CD52 for CLL tx

24
Q

What is the target of Bevacizumab and what are its main uses?

A

VEGF for tx of colorectal cancer, renal cell carcinoma

25
Q

What is the target of Cetuximab and what are its main uses?

A

EGFR for tx of stage IV CRR and head/neck cancer

26
Q

What is the target of Rituximab and what are its main uses?

A

CD20 for tx of B-cell non-Hodgkine lymphoma, CLL, rheumatoid arthritis, and ITP

27
Q

What is the target of Adalimumab and infliximab and what are its main uses?

A

Soluble TNF-a for x of IBD, rheumatoid arthritis, ankylosing spondylitis, and psoriasis

28
Q

What is Etanercept?

A

A decoy TNF-a receptor (not an MAB)

29
Q

What is the target of Eculizumab and what are its main uses?

A

Complement protein C5 for tx of paroxysmal nocturnal hemoglobinuria

30
Q

What is the target of natalizumab and what are its main uses?

A

a4-integrin for tx of MS and Crohn disease

31
Q

What is the target of Abciximab and what are its main uses?

A

Platelet glycoproteins IIb/IIIa for prevention of ischemic complications in pts udnergoing percuraneous coronary interventon

32
Q

What is the target of Denosumab and what are its main uses?

A

RANKL for tx of osteoporosis (inhibits osteoCLAST maturation and mimic osteoportergerin)

33
Q

What is the target of Digoxin immune Fab and what are its main uses?

A

Digoxin for digoxin toxicity

34
Q

What is the target of omalizumab and what are its main uses?

A

IgE for tx of allergic astham (prevents IgE from binding to FceR1)

35
Q

What is the target of Palivizumab and what are its main uses?

A

RSV F protein for RSF prophyalxis in high-risk infants

36
Q

What is the target of Ranibizumab and what are its main uses?

A

VEGF for tx of neovascular age-related macular degen (can also use bevacizumab and other drugs)

STEP 1 (5) (11 decks)

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