pharm quiz 6

Question 1

silent killer

Answer 1

hypertension

Question 2

untreated HTN leads to

Answer 2

atherosclerosis and congestive heart failure

Question 3

high bp for pt less than 60 years/kidney disease/ or DM

Answer 3

140/90

Question 3

high bp in pts over 60

Answer 3

150/90

Question 4

primary HTN

Answer 4

AKA: idiopathic
90% of population

Question 5

secondary HTN

Answer 5

10% of population

Question 6

blood pressure =?

Answer 6

COxSVR=BP

Question 7

SVR=?

Answer 7

vasoconstriction/dilation

Question 8

cardiac output =?

Answer 8

SVxHR
48L/min

Question 9

normal SV in adults

Answer 9

about 70mL

Question 10

preload

Answer 10

amount of blood going into the heart (volume)

Question 11

afterload

Answer 11

the amount of blood going out of the heart (pressure)

Question 11

sympathetic nervous system receptors

Answer 11

alpha 1
alpha 2
beta 1
beta 2
dopamine

Question 11

2 things that make up cardiac output

Answer 11

cardiac factors and circulating volume

Question 12

sympathetic neurotransmitter

Answer 12

norepinephrine

Question 13

alpha 1 receptors activated by what and affects what

Answer 13

NE; vasoconstriction, constriction of sphincters of GI and GU tract, mydriasis of pupil

Question 14

alpha 1 blockers MOA

Answer 14

prevents NE from causing vasoconstriction; relaxes smooth muscle around the prostate and bladder neck

Question 15

A1 indications

Answer 15

HTN, relieve symptoms of benign prostatic hyperplasia, manage severe HF

Question 16

A1 SE

Answer 16

• orthostatic HTN
• first dose effect (drops BP)
• dizziness
• HA
• nasal congestion
• decreased libido
• impotence

Question 17

A1 teaching

Answer 17

rebound HTN if d/c

Question 18

A1 additive effects

Answer 18

• when given with other anti-HTN meds
• check trends
• question of SBP <110

Question 19

A1 examples

Answer 19

doxaZOSIN
teraZOSIN
tamsulosin

Question 19

Alpha 2 angonist MOA

Answer 19

• centrally acting
• stimulate a2-adrenergic receptors in the brain
• decreased sympathetic outflow from CNS

Question 20

A2 agonist indications

Answer 20

• HTN
• dysmenorrhea
• menopausal flushing
• glaucoma
• migraines
• manage withdrawal symptoms

Question 21

A2 agonist teaching

Answer 21

• don’t d/c abruptly –> rebound HTN
• hypotension
• additive effects

Question 22

A2 agonist examples

Answer 22

• clonidine
• methyldopa

Question 23

methyldopa is DOC for what

Answer 23

HTN in pregnancy

Question 24

Beta 1 receptors in the heart do what

Answer 24

• HR
• force of contraction
• velocity of conduction in AV node

Question 25

beta 1 receptors in pancreas

Answer 25

decreased insulin

Question 25

Beta 1 receptors in kidneys

Answer 25

renin release