Pharm Projects

Question 0

MOA of aspirin

Answer 0

Irreversibly binds COX1

Question 1

Only selective NSAID

Answer 1

Celebrex

Question 2

5 presented NSAIDs

Answer 2

Ibuprofen
Naproxen
Aspirin
Mobic
Celebrex

Question 3

Antiphospholipid syndrome

Answer 3

Autoimmune hypercoagulable disease

Arterial and venous clots

Question 4

Most common victim of antiphospholipid syndrome

Answer 4

Young women

Can lead to pregnancy morbidity

Question 5

Primary vs secondary APS

Answer 5

Primary: not linked to any disease
Secondary: along with another autoimmune disease, particularly lupus

Question 6

APS present in what percent of cases with DVTs

Answer 6

15-20%

Question 7

Drugs used for APS therapy

Answer 7

Warfarin
Aspirin
Clopidogrel

Question 8

Perfusion relevance of APS

Answer 8

Risk of thrombosis

Impaired anticoagulation

Question 9

Anticoagulation management for neonates and Peds

Answer 9

Newborn-1yr: 600U/kg Hep
1-5yr: 500U/kg
5yr: 450U/kg
Pump dose: 100U/kg

Question 10

Neonate BP management during cooling and rewarming

Answer 10

Cooling: 20-70
Rewarming: 30-70

Question 11

Affects of pregnancy during 3rd term

Answer 11

Increased CO, BV, HR,SV
Increased clotting factors 1,2,7,8,9,12
Decreased protein C and S
Increased PAI-1 and 2

Question 12

How high should you keep MAP of a gravid pt?

Answer 12

> 65

Question 13

FDA gravid. Drug categories

Answer 13

A: safest
B
C
D: fetal risk

Best drugs are alpha or beta agonists (keep BP high)

Question 14

Contributions to vasoplegic syndrome

Answer 14

Endothelial injury: Vasopressin impairment, thrombin activation
Exposure to foreign surface area
Exposure to cardiotomy blood 
XC removal
SIRS

Question 15

Ultimate indicator of VPS

Answer 15

MAP <50

Low SVR

Question 16

Vasoplegic syndrome treatment

Answer 16

High dose of vasopressors Postop: phenylephrine, NE, dopamine, methylene blue

Question 17

Drugs to avoid on bypass with renal failure

Answer 17

Lepirudin, Bivalirudin,Warfarin

Question 18

Antibiotics used on bypass with. Renal failure

Answer 18

Cefazolin
Cefuroxime
Vancomycin
Clindamycin

Question 19

2 things to consider. With liver failure patients

Answer 19

Impaired production of clotting factors

Impairment of detoxification functions

Question 20

2 stages of Hyperthermic intraperitoneal chemotherapy

Answer 20

1st: cytoreductive surgery
2: HIPEC

Question 21

HIPEC drugs

Answer 21

Mitomycin C
Cisplatin
Oxaliplatin
Melphalan
Doxorubicin

Question 22

Causes of lipid dyscrasia

Answer 22

Elevated cholesterol

Question 23

What must you avoid on bypass with lipid dyscrasia?

Answer 23

Stasis

Question 24

Cause of normocytic/normothermic anemia

Answer 24

Sudden blood loss

Question 25

Cause of microcytic/Hypochromic anemia

Answer 25

Iron deficiency

Question 26

Sickle cell anemia treatment on bypass

Answer 26

Maintain HCT above 24%
Prevent hypothermia
VO2>80
Use crystalloid cardioplegia 
Hemoconcentrate