pharm oral

Question 1

Endogenous and Synthetic catecholamines

EPI: ^ENDOGENOUS CATECHOLAMINE AND NONSELECTIVE ADRENERGIC AGONIST

NOREPI: _DIRECT ACTING ^ENDOGENOUS CATECHOLAMINE AND ADRENERGIC AGONIST

DOPAmine: ^ENDOGENOUS CATECHOLAMINE AND ADRENERGIC AGONIST

DOBUTamine: SYMPATHOMIMETIC SYNTHETIC CATECHOLAMINE, B1 SELECTIVE AGONIST

VASOPRESSIN: EXOGENOUS ANTIDIURETIC PEPTIDE AND VASOPRESSOR

ISOPRETERONOL: SYNTHETIC CATECHOLAMINE, B1>B2 MINIMAL ALPHA

EPHEDRINE: SYNTHETHIC NON CATECHOLAMINE, DIRECT AND INDIRECT ADRENERGIC AGONIST

PHENYLEPHRINE: SYNTHETIC NON CATECHOLAMINE _DIRECT ACTING SELECTIVE ALPHA 1

Answer 1

MOA:
EPI, NOREPI, DOBUTAMINE, ISOPRETERONOL ACT ON G PROTEINS TO INCREASE CAMP RESULTING IN INCREASED CONTRACTILITY

EPI/NE: STIMULATES ALPHA AND BETA RECEPTORS
E: BETA>ALPHA. NE: ALPHA AND BETA1 > B2;

DOPAMINE: DIRECTLY STIMUYLATES DOPAMINERGIC, ALPHA AND BETA RECEPTORS. EXTRACTED FROM L=DOPA IN CATECHOLAMINES

SYNTHESIS OF TYROSINE

DOBUTAMINE: GOOD FOR CHF

VASOPRESSIN: ACTS ON RENAL TUBES TO RETAIN WATER, CONSTRICT THE EFFERENT ARTERIOLE, INCREASES VWF, FACT 8

ISOPROTERONOL: PULM AND SYSTEMIC VASODILATOR

EPHEDRINE: INDIRECTLY affects alpha and beta by stim NE release. DIRECTLY acts on BETA1 (increase bp, map, contractility)

Phenylephrine: direct stimulation of alpha 1 receptors. venous>arterial constriction. increase bp, map

Pharmaco:

onset: rapid
doa: 5-10 min (ephredine: 1 hr)

e1/2t: short (1-2 min) (except Vasopressin (10-20 min, ephedrine (3 hrs).

metabolism and elimination (epi,ne,DOBUT,DOPA): MAO, COMT reuptake or diffusion away.

(DOPAmine- moa, comt to 75% inactive adn 25% NE.

vasopressin: