Pharm Module 1 Flashcards
1
Q
how to calculate bioavailability
A
area under curve for IV drugs
2
Q
IV route has what bioavailablity
A
- 100%
3
Q
when is the bioavailability of drugs measured
A
- after the first pass effect
4
Q
acidic drugs bind what
A
- albumin
5
Q
basic drugs bind what
A
- alpha1 acidic glycoprotein
6
Q
hydrophobic drugs bind what
A
- lipoproteins
7
Q
steroid hormones bind what
A
- globulins
8
Q
what part of the drug can be cleared renally?
A
- the free, unbound fraction of the drug
9
Q
if you have a high volume of distribution, where does the drug go?
A
- little in the plasma
- more in the interstitial and intracellular fluid
10
Q
if you have a low volume of distribution, where does the drug go?
A
- more in the plasma
11
Q
how to calculate volume of distribution
A
Vd = Q/Cp
Q= amount of drug in body Cp= plasma drug concentration
12
Q
Clearance and plasma concentration of a drug with high Vd
A
- low clearance
- low plasma concentration
13
Q
clearance and plasma concentration of a drug with low Vd
A
- high clearance
- high plasma concentration
14
Q
how to calculate renal clearance
A
CL = UV/P
U= drug concentration in urine V = flow rate P = plasma concentration of drug
15
Q
half life of drug formula considering CL
A
t1/2 = (0.7*Vd)/CL
