Pathoma Nephritic Syndromes Flashcards
what are nephritic syndromes
- glomerular disorders characterized by glomerular infiltration and bleeding
symptoms of nephritic syndromes
- limited proteinuria <3.5g/day
- oliguria and azotemia
- salt retention and periorbital edema and hypertension
- RBC casts and dysmorphic RBCs in urine
biopsy of nephritic syndromes reveals
- hypercellular, inflammed glomeruli
cause of post-streptococcal glomerulonephritis
- Nephritic Syndrome arising after group A beta hemolytic strep infection of skin or pharynx
post-streptococcal glomerulonephritis occurs with what strains
- nephritogenic
post-streptococcal glomerulonephritis may occur with what other strains
- non streptococcal
post-streptococcal glomerulonephritis presents ______ weeks after infection with
- 2-3 weeks
- hematuria, oliguria, hypertension, and perioribtal edema
post-streptococcal glomerulonephritis usually seen in what population
- children
post-streptococcal glomerulonephritis mediated by
- immune complex deposition
post-streptococcal glomerulonephritis - what is seen on immune fluorescence
- granular
post-streptococcal glomerulonephritis - what is seen on electron microscopy
- sub epithelial humps
post-streptococcal glomerulonephritis treatment
- supportive
rapidly progressing glomerulonephritis is what kind of syndrome
- nephritic syndrome
rapidly progressing glomerulonephritis progresses to renal failure when
- weeks to months
rapidly progressing glomerulonephritis characterized by
- crescents in Bowman’s space of glomeruli
rapidly progressing glomerulonephritis - crescents are composed of
- fibrin and macrophages
linear IF pattern of rapidly progressing glomerulonephritis associated with what disease
- goodpasture
pathology of goodpasture
- antibody against collagen in glomerular and alveolar basement membranes
goodpasture presents as
- hematuria and hemoptysis
good pasture seen in which population
- young, adult males
rapidly progressing glomerulonephritis - granular IF due to
- immune complex deposition
rapidly progressing glomerulonephritis - granular IF diseases
which is the most common
- poststreptococcal glomerulonephritis (most common)
- diffuse proliferative glomerulonephritis
diffuse proliferative glomerulonephritis is due to
where
- antigen-antibody complex deposition
- sub endothelial
what is the most common type of renal disease in SLE
- diffuse proliferative glomerulonephritis
rapidly progressing glomerulonephritis - negative IF also called
- pauci-immune
rapidly progressing glomerulonephritis - negative IF due to which conditions
- wegener granulomatosis
- microscopic polyangiitis
- Churg-Strauss
wegener granulomatosis associated with which ANCA
- c-ANCA
microscopic polyangiitis and Churg Strauss associated with which ANCA
- p-ANCA
what distinguishes Churg Strauss from microscopic polyangiitis
- granulomatous inflammation
- eosinophilia
- asthma
IgA nephropathy also called
- Berger disease
IgA nephropathy pathology
- IgA immune complex deposition in mesangium of glomeruli
what is the most common nephropathology worldwide
- IgA nephropathy
IgA nephropathy presents during
as what
- childhood
- episodic gross or microscopic hematuria with RBC casts following mucosal infections
why is IgA nephropathy worse after mucosal infections
- IgA production is increased during infection
IgA nephropathy - what is seen on IF
- IgA immune complex deposition in the mesangium
IgA nephropathy may slowly progress to
- renal failure
alport syndrome caused by
- inherited defect in Type IV collagen
alport syndrome genetics
- X-linked
alport syndrome results in
- thinning and splitting of glomerular basement membrane
alport syndrome presents as
- isolated hematuria
- sensory hearing loss
- ocular disturbances
