Pathoma Nephritic Syndromes Flashcards

(40 cards)

1
Q

what are nephritic syndromes

A
  • glomerular disorders characterized by glomerular infiltration and bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

symptoms of nephritic syndromes

A
  • limited proteinuria <3.5g/day
  • oliguria and azotemia
  • salt retention and periorbital edema and hypertension
  • RBC casts and dysmorphic RBCs in urine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

biopsy of nephritic syndromes reveals

A
  • hypercellular, inflammed glomeruli
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

cause of post-streptococcal glomerulonephritis

A
  • Nephritic Syndrome arising after group A beta hemolytic strep infection of skin or pharynx
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

post-streptococcal glomerulonephritis occurs with what strains

A
  • nephritogenic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

post-streptococcal glomerulonephritis may occur with what other strains

A
  • non streptococcal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

post-streptococcal glomerulonephritis presents ______ weeks after infection with

A
  • 2-3 weeks

- hematuria, oliguria, hypertension, and perioribtal edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

post-streptococcal glomerulonephritis usually seen in what population

A
  • children
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

post-streptococcal glomerulonephritis mediated by

A
  • immune complex deposition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

post-streptococcal glomerulonephritis - what is seen on immune fluorescence

A
  • granular
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

post-streptococcal glomerulonephritis - what is seen on electron microscopy

A
  • sub epithelial humps
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

post-streptococcal glomerulonephritis treatment

A
  • supportive
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

rapidly progressing glomerulonephritis is what kind of syndrome

A
  • nephritic syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

rapidly progressing glomerulonephritis progresses to renal failure when

A
  • weeks to months
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

rapidly progressing glomerulonephritis characterized by

A
  • crescents in Bowman’s space of glomeruli
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

rapidly progressing glomerulonephritis - crescents are composed of

A
  • fibrin and macrophages
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

linear IF pattern of rapidly progressing glomerulonephritis associated with what disease

18
Q

pathology of goodpasture

A
  • antibody against collagen in glomerular and alveolar basement membranes
19
Q

goodpasture presents as

A
  • hematuria and hemoptysis
20
Q

good pasture seen in which population

A
  • young, adult males
21
Q

rapidly progressing glomerulonephritis - granular IF due to

A
  • immune complex deposition
22
Q

rapidly progressing glomerulonephritis - granular IF diseases

which is the most common

A
  • poststreptococcal glomerulonephritis (most common)

- diffuse proliferative glomerulonephritis

23
Q

diffuse proliferative glomerulonephritis is due to

where

A
  • antigen-antibody complex deposition

- sub endothelial

24
Q

what is the most common type of renal disease in SLE

A
  • diffuse proliferative glomerulonephritis
25
rapidly progressing glomerulonephritis - negative IF also called
- pauci-immune
26
rapidly progressing glomerulonephritis - negative IF due to which conditions
- wegener granulomatosis - microscopic polyangiitis - Churg-Strauss
27
wegener granulomatosis associated with which ANCA
- c-ANCA
28
microscopic polyangiitis and Churg Strauss associated with which ANCA
- p-ANCA
29
what distinguishes Churg Strauss from microscopic polyangiitis
- granulomatous inflammation - eosinophilia - asthma
30
IgA nephropathy also called
- Berger disease
31
IgA nephropathy pathology
- IgA immune complex deposition in mesangium of glomeruli
32
what is the most common nephropathology worldwide
- IgA nephropathy
33
IgA nephropathy presents during as what
- childhood | - episodic gross or microscopic hematuria with RBC casts following mucosal infections
34
why is IgA nephropathy worse after mucosal infections
- IgA production is increased during infection
35
IgA nephropathy - what is seen on IF
- IgA immune complex deposition in the mesangium
36
IgA nephropathy may slowly progress to
- renal failure
37
alport syndrome caused by
- inherited defect in Type IV collagen
38
alport syndrome genetics
- X-linked
39
alport syndrome results in
- thinning and splitting of glomerular basement membrane
40
alport syndrome presents as
- isolated hematuria - sensory hearing loss - ocular disturbances