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Renal Final > Pathoma Nephritic Syndromes > Flashcards

Pathoma Nephritic Syndromes Flashcards

1
Q

what are nephritic syndromes

A
  • glomerular disorders characterized by glomerular infiltration and bleeding
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2
Q

symptoms of nephritic syndromes

A
  • limited proteinuria <3.5g/day
  • oliguria and azotemia
  • salt retention and periorbital edema and hypertension
  • RBC casts and dysmorphic RBCs in urine
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3
Q

biopsy of nephritic syndromes reveals

A
  • hypercellular, inflammed glomeruli
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4
Q

cause of post-streptococcal glomerulonephritis

A
  • Nephritic Syndrome arising after group A beta hemolytic strep infection of skin or pharynx
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5
Q

post-streptococcal glomerulonephritis occurs with what strains

A
  • nephritogenic
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6
Q

post-streptococcal glomerulonephritis may occur with what other strains

A
  • non streptococcal
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7
Q

post-streptococcal glomerulonephritis presents ______ weeks after infection with

A
  • 2-3 weeks

- hematuria, oliguria, hypertension, and perioribtal edema

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8
Q

post-streptococcal glomerulonephritis usually seen in what population

A
  • children
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9
Q

post-streptococcal glomerulonephritis mediated by

A
  • immune complex deposition
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10
Q

post-streptococcal glomerulonephritis - what is seen on immune fluorescence

A
  • granular
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11
Q

post-streptococcal glomerulonephritis - what is seen on electron microscopy

A
  • sub epithelial humps
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12
Q

post-streptococcal glomerulonephritis treatment

A
  • supportive
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13
Q

rapidly progressing glomerulonephritis is what kind of syndrome

A
  • nephritic syndrome
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14
Q

rapidly progressing glomerulonephritis progresses to renal failure when

A
  • weeks to months
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15
Q

rapidly progressing glomerulonephritis characterized by

A
  • crescents in Bowman’s space of glomeruli
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16
Q

rapidly progressing glomerulonephritis - crescents are composed of

A
  • fibrin and macrophages
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17
Q

linear IF pattern of rapidly progressing glomerulonephritis associated with what disease

A
  • goodpasture
18
Q

pathology of goodpasture

A
  • antibody against collagen in glomerular and alveolar basement membranes
19
Q

goodpasture presents as

A
  • hematuria and hemoptysis
20
Q

good pasture seen in which population

A
  • young, adult males
21
Q

rapidly progressing glomerulonephritis - granular IF due to

A
  • immune complex deposition
22
Q

rapidly progressing glomerulonephritis - granular IF diseases

which is the most common

A
  • poststreptococcal glomerulonephritis (most common)

- diffuse proliferative glomerulonephritis

23
Q

diffuse proliferative glomerulonephritis is due to

where

A
  • antigen-antibody complex deposition

- sub endothelial

24
Q

what is the most common type of renal disease in SLE

A
  • diffuse proliferative glomerulonephritis
25
Q

rapidly progressing glomerulonephritis - negative IF also called

A
  • pauci-immune
26
Q

rapidly progressing glomerulonephritis - negative IF due to which conditions

A
  • wegener granulomatosis
  • microscopic polyangiitis
  • Churg-Strauss
27
Q

wegener granulomatosis associated with which ANCA

A
  • c-ANCA
28
Q

microscopic polyangiitis and Churg Strauss associated with which ANCA

A
  • p-ANCA
29
Q

what distinguishes Churg Strauss from microscopic polyangiitis

A
  • granulomatous inflammation
  • eosinophilia
  • asthma
30
Q

IgA nephropathy also called

A
  • Berger disease
31
Q

IgA nephropathy pathology

A
  • IgA immune complex deposition in mesangium of glomeruli
32
Q

what is the most common nephropathology worldwide

A
  • IgA nephropathy
33
Q

IgA nephropathy presents during

as what

A
  • childhood

- episodic gross or microscopic hematuria with RBC casts following mucosal infections

34
Q

why is IgA nephropathy worse after mucosal infections

A
  • IgA production is increased during infection
35
Q

IgA nephropathy - what is seen on IF

A
  • IgA immune complex deposition in the mesangium
36
Q

IgA nephropathy may slowly progress to

A
  • renal failure
37
Q

alport syndrome caused by

A
  • inherited defect in Type IV collagen
38
Q

alport syndrome genetics

A
  • X-linked
39
Q

alport syndrome results in

A
  • thinning and splitting of glomerular basement membrane
40
Q

alport syndrome presents as

A
  • isolated hematuria
  • sensory hearing loss
  • ocular disturbances

Renal Final (13 decks)

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