Pharm General Concepts

Question 1

enzyme expressed in the outer zone of the adrenal cortex; cells contain receptor for ANG II

Answer 1

CYP11B2 = aldosterone synthase

Question 2

Enzymes expressed by the zona fasciculata for the production of glucocorticoids

Answer 2

CYP17 = steroid 17-alpha-hydroxylase
CYP11B1 = 11-beta-hydroxylase

Question 3

Enzyme that catalyzes a lyase reaction to convert C21 corticosteroids to C19 androgen precursors in the zona reticularis

Answer 3

CYP17

Question 4

Rate-limiting step in steroid hormone production

Answer 4

conversion of cholesterol to pregnenolone (catalyzed by CYP11A1). The rate-limiting components in this reaction regulate the mobilization of cholesterol & its delivery to CYP11A1 in the inner mitochondrial matrix.

Question 5

What stimulates mobilization of cholesterol to the inner mitochondrial matrix?

Answer 5

ACTH

Question 6

Liver enzyme transcription that is induced by glucocorticoids

Answer 6

Enzymes of gluconeogenesis:

1. PEPCK
2. G-6-P
3. fructose-2,6-bisphosphatase