Pharm Exam III Numbers

Question 1

How much more is CO₂ diffusable than O₂?

Answer 1

20x

Question 2

How quickly will N₂O diffuse into the air-filled cavity?

Answer 2

10 L in 10-15 minutes

Question 3

Blood:Gas Partition Coefficients: Halothane

Answer 3

2.54

Question 4

Blood:Gas Partition Coefficients: N₂O

Answer 4

0.46

Question 5

Blood:Gas Partition Coefficients: Desflurane

Answer 5

0.42

Question 6

Blood:Gas Partition Coefficients: Isoflurane

Answer 6

1.46

Question 7

Blood:Gas Partition Coefficients: Sevoflurane

Answer 7

0.69

Question 8

MAC_awake

Answer 8

0.3-0.5

Question 9

MAC_BAR

Answer 9

1.7-2.0 MAC

Question 10

MAC: N₂O

Answer 10

104

Question 11

MAC: Halothane

Answer 11

0.75

Question 12

MAC: Isoflurane

Answer 12

1.17

Question 13

MAC: Desflurane

Answer 13

6.6

Question 14

MAC: Sevoflurane

Answer 14

1.8

Question 15

MAC Age: 55-60

Answer 15

-6% per decade

Question 16

MAC Age: 30-55

Answer 16

+/- 0%

Question 17

MAC Age: 10s

Answer 17

+12%

Question 18

MAC Age: peak

Answer 18

1 year old

Question 19

MAC Age: 20s

Answer 19

+6%

Question 20

MAC Age: 70s

Answer 20

-12%

Question 21

No change in MAC: P_aCO₂

Answer 21

15-95 mmHg

Question 22

No change in MAC: P_aO₂

Answer 22

> 38 mmHg

Question 23

Vapor Pressure: Halothane

Answer 23

243 mmHg

Question 24

Vapor Pressure: Isoflurane

Answer 24

238 mmHg

Question 25

Vapor Pressure: Desflurane

Answer 25

669 mmHg

Question 26

Vapor Pressure: Sevoflurane

Answer 26

157 mmHg

Question 27

MAC: Burst Supression

Answer 27

1.5 MAC

Question 28

MAC: Electrical Silence (Brain Death)

Answer 28

2 MAC

Question 29

MAC: Dose related decrease in amplitude and increase in latency for both SSEP and MEP

Answer 29

0.5-1.5 MAC

Question 30

Autoregulation of CBF

Answer 30

60-160 mmHg

Question 31

MAC Loss of Autoregulation CBF: Halothane

Answer 31

0.5 MAC

Question 32

MAC of Autoregulation CBF: Sevoflurane

Answer 32

1 MAC

Question 33

MAC Loss of Autoregulation CBF: Isoflurane & Desflurane

Answer 33

0.5-1.5 MAC

Question 34

MAC: Increased ICP

Answer 34

Onset > 0.8 MAC

Question 35

Amount increase in ICP by anesthesia

Answer 35

7 mmHg

Question 36

MAC: Apnea

Answer 36

1.5-2.0 MAC

Question 37

MAC: Blunt hypoxic response (COPD)

Answer 37

50-70% depression: 0.1 MAC
100% depression: 1.1 MAC

Question 38

MAC: Hypoxic Pulmonary Vasoconstriction

Answer 38

50% depression at 2 MAC

Question 39

MAC: Sevo increases HR

Answer 39

> 1.5 MAC

Question 40

Hepatotoxicity: Type I

Answer 40

1-2 weeks after exposure
20% of patients

Question 41

Hepatotoxicity: Type II

Answer 41

1 month after exposure

Question 42

MAC: Increased portal vein flow

Answer 42

1-1.5 MAC

Question 43

MAC: N₂O vomiting

Answer 43

> 0.5 MAC

Question 44

MAC: Obstetric Effects

Answer 44

0.5-1.0 MAC

Question 45

1 Hz: Seconds

Answer 45

1 second

Question 46

TOFR: Amplitude of 4th twitch is 50% of the 1st

Answer 46

0.5

Question 47

TOFR: Experienced anesthetists’ unable to detect fade

Answer 47

> 0.4

Question 48

TOFR: Significant residual

Answer 48

0.7-0.9

Question 50

Bedside extubation criteria..

Answer 50

P_IP = 25-30 cmH₂O

Question 51

Succinylcholine: Dose

Answer 51

1 mg/kg

Question 52

Succinylcholine: Onset

Answer 52

30-60 seconds

Question 53

Succinylcholine: Duration

Answer 53

3-5 minutes

Question 54

Succinylcholine: K⁺ leak

Answer 54

0.5 mEq/L

Question 55

TOFR: Phase I Block

Answer 55

> 0.7

Question 56

Succinylcholine: Overdose

Answer 56

2-4 mg/kg

Question 57

Succinylcholine: duration if dibucaine number is 20

Answer 57

3 hours (normal dose)

Question 58

Succinylcholine: Increased intraocular pressure

Answer 58

Maximum increase 2-4 minutes after administration
Lasts 5-10 minutes (transient)

Question 59

Fasciculation dose of non-depolarizing NMBD

Answer 59

1/10th of Vec or Roc dose

Question 60

Dantrolene: Dose

Answer 60

2.0 mg/kg; max 10mg/kg

Question 61

MAC: Ischemic Preconditioning

Answer 61

0.25 MAC

Question 62

What is the temperature in the OR?

Answer 62

20-22^o

Question 63

What is the temperature in the absorber?

Answer 63

40-60^o

Question 64

How much moisture is in soda lime?

Answer 64

15%

Question 65

NIOSH limits for potent anesthetics

Answer 65

2ppm; 25ppm for N₂O

Question 66

How long will it take for the brain to equalize with the spinal cord?

Answer 66

10-15 minutes

Question 67

N₂O reduces MAC by…

Answer 67

1% for each % of N₂O

Question 68

MAC decreases by 50% for each…

Answer 68

10^o decrease in temperature

Question 69

Tetanic stimulation

Answer 69

50 hz for 5 seconds

Question 70

Post-tetanic stimulation

Answer 70

1 twitch 3 seconds after stimulation

Question 71

Synaptic Cleft

Answer 71

20-50 nm wide

Question 72

Ready Release Vesicles

Answer 72

5,000-10,000

Question 73

Pentameric unit

Answer 73

5 sub pores

Question 74

Succinylcholine: MG Dose

Answer 74

1.5-2mg/kg