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Spring 2024 > Pharm Exam III Numbers > Flashcards

Pharm Exam III Numbers Flashcards

All answers are numbers

1
Q

How much more is CO2 diffusable than O2?

A

20x

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2
Q

How quickly will N2O diffuse into the air-filled cavity?

A

10 L in 10-15 minutes

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3
Q

Blood:Gas Partition Coefficients: Halothane

A

2.54

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4
Q

Blood:Gas Partition Coefficients: N2O

A

0.46

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5
Q

Blood:Gas Partition Coefficients: Desflurane

A

0.42

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6
Q

Blood:Gas Partition Coefficients: Isoflurane

A

1.46

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7
Q

Blood:Gas Partition Coefficients: Sevoflurane

A

0.69

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8
Q

MACawake

A

0.3-0.5

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9
Q

MACBAR

A

1.7-2.0 MAC

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10
Q

MAC: N2O

A

104

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11
Q

MAC: Halothane

A

0.75

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12
Q

MAC: Isoflurane

A

1.17

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13
Q

MAC: Desflurane

A

6.6

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14
Q

MAC: Sevoflurane

A

1.8

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15
Q

MAC Age: 55-60

A

-6% per decade

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16
Q

MAC Age: 30-55

A

+/- 0%

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17
Q

MAC Age: 10s

A

+12%

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18
Q

MAC Age: peak

A

1 year old

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19
Q

MAC Age: 20s

A

+6%

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20
Q

MAC Age: 70s

A

-12%

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21
Q

No change in MAC: PaCO2

A

15-95 mmHg

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22
Q

No change in MAC: PaO2

A

> 38 mmHg

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23
Q

Vapor Pressure: Halothane

A

243 mmHg

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24
Q

Vapor Pressure: Isoflurane

A

238 mmHg

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25
Q

Vapor Pressure: Desflurane

A

669 mmHg

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26
Q

Vapor Pressure: Sevoflurane

A

157 mmHg

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27
Q

MAC: Burst Supression

A

1.5 MAC

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28
Q

MAC: Electrical Silence (Brain Death)

A

2 MAC

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29
Q

MAC: Dose related decrease in amplitude and increase in latency for both SSEP and MEP

A

0.5-1.5 MAC

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30
Q

Autoregulation of CBF

A

60-160 mmHg

31
Q

MAC Loss of Autoregulation CBF: Halothane

A

0.5 MAC

32
Q

MAC of Autoregulation CBF: Sevoflurane

A

1 MAC

33
Q

MAC Loss of Autoregulation CBF: Isoflurane & Desflurane

A

0.5-1.5 MAC

34
Q

MAC: Increased ICP

A

Onset > 0.8 MAC

35
Q

Amount increase in ICP by anesthesia

A

7 mmHg

36
Q

MAC: Apnea

A

1.5-2.0 MAC

37
Q

MAC: Blunt hypoxic response (COPD)

A

50-70% depression: 0.1 MAC
100% depression: 1.1 MAC

38
Q

MAC: Hypoxic Pulmonary Vasoconstriction

A

50% depression at 2 MAC

39
Q

MAC: Sevo increases HR

A

> 1.5 MAC

40
Q

Hepatotoxicity: Type I

A

1-2 weeks after exposure
20% of patients

41
Q

Hepatotoxicity: Type II

A

1 month after exposure

42
Q

MAC: Increased portal vein flow

A

1-1.5 MAC

43
Q

MAC: N2O vomiting

A

> 0.5 MAC

44
Q

MAC: Obstetric Effects

A

0.5-1.0 MAC

45
Q

1 Hz: Seconds

A

1 second

46
Q

TOFR: Amplitude of 4th twitch is 50% of the 1st

A

0.5

47
Q

TOFR: Experienced anesthetists’ unable to detect fade

A

> 0.4

48
Q

TOFR: Significant residual

A

0.7-0.9

49
Q
A
50
Q

Bedside extubation criteria..

A

PIP = 25-30 cmH2O

51
Q

Succinylcholine: Dose

A

1 mg/kg

52
Q

Succinylcholine: Onset

A

30-60 seconds

53
Q

Succinylcholine: Duration

A

3-5 minutes

54
Q

Succinylcholine: K+ leak

A

0.5 mEq/L

55
Q

TOFR: Phase I Block

A

> 0.7

56
Q

Succinylcholine: Overdose

A

2-4 mg/kg

57
Q

Succinylcholine: duration if dibucaine number is 20

A

3 hours (normal dose)

58
Q

Succinylcholine: Increased intraocular pressure

A

Maximum increase 2-4 minutes after administration
Lasts 5-10 minutes (transient)

59
Q

Fasciculation dose of non-depolarizing NMBD

A

1/10th of Vec or Roc dose

60
Q

Dantrolene: Dose

A

2.0 mg/kg; max 10mg/kg

61
Q

MAC: Ischemic Preconditioning

A

0.25 MAC

62
Q

What is the temperature in the OR?

A

20-22o

63
Q

What is the temperature in the absorber?

A

40-60o

64
Q

How much moisture is in soda lime?

A

15%

65
Q

NIOSH limits for potent anesthetics

A

2ppm; 25ppm for N2O

66
Q

How long will it take for the brain to equalize with the spinal cord?

A

10-15 minutes

67
Q

N2O reduces MAC by…

A

1% for each % of N2O

68
Q

MAC decreases by 50% for each…

A

10o decrease in temperature

69
Q

Tetanic stimulation

A

50 hz for 5 seconds

70
Q

Post-tetanic stimulation

A

1 twitch 3 seconds after stimulation

71
Q

Synaptic Cleft

A

20-50 nm wide

72
Q

Ready Release Vesicles

A

5,000-10,000

73
Q

Pentameric unit

A

5 sub pores

74
Q

Succinylcholine: MG Dose

A

1.5-2mg/kg

Spring 2024 (9 decks)

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