pharm exam 2

Question 1

testesterone uses (5)

Answer 1

-hypogonadism
-anemia
-growth delay
-gender transitioning f-m
osteoporosis in men

Question 2

testesterone physiological effects (4)

Answer 2

-virilization (dvpt of male characteristics in females)
-accessory sexual organs
-inc. RBC & platelet production
-bone & muscle growth

Question 3

testesterone considerations

Answer 3

Apply to skin other than scrotum and bony areas
Check serum lipid levels regularly
-risk for abuse, physical & psychological dependence

Question 4

testesterone side effects

Answer 4

Abdominal pain, nausea, diarrhea, constipation, hives, irritation at injection site, increased salivation, mouth soreness, increased or decreased libido, insomnia, acne, masculinization, irregular menses, urinary urgency, gynecomastia (enlargement of breast tissue in men) etc.

Question 5

testesterone adverse effects

Answer 5

Aggressive behavior
Hyperglycemia - DM
Priapism (long lasting painful erection)
Venous thromboembolism
Hepatotoxicity
Na+ & H2O retention
Polycythemia
Hypertension
BPH (benign prostatic hyperplasia)
Hyperlipidemia
Liver damage/necrosis

Question 6

oxandrolone (an anabolic steroid)

Answer 6

delayed puberty
hypogonadism
muscle loss in cancer and AIDS
osteoporosis
breast cancer (palliative)

Question 7

anabolic
bone & muscle development
strength and power
androgenic
sexual characteristics
euphoria & enhanced sexual performance
changes in mood and behavior

which medication?

Answer 7

oxandrole (an anabolic steroid). has anabolic, androgenic, euphria & enhanced sexual performance
-changes in mood and behavior

hint: ouphoria

Question 8

which med increases risk of MI and CVA (stroke)

Answer 8

anabolic steroids (oxandrolone)
long term effects
-Renal impairment
Liver damage
Cardiomegaly
Hypertension
Elevated cholesterol

Question 9

what mimics testesterone?

Answer 9

anabolic steroids (oxandrolone)
its a synthetic testesterone that inhibits FSF and LH, so the body is not able to produce sperm. it also inc. risk of prostate cancer in men

in women, it causes hirsutism (women have excess androgen male hormones, like testesterone causing them to have mustache, beard, etc..
pattern baldness of patients AMAB
changes in or stop in the menstrual cycle
enlarged clitoris
deepened voice

Question 10

anabolic steroids adverse affects?
neurological?
cardio?
gastrointestinal effects?
mental health problems?

Answer 10

anabolic steroids adverse affects?
neurological? stroke
cardio? cardiomyopathy, cardiovascular damage, water retention
gastrointestinal effects? Liver damage, high LDL, low HDL
mental health problems? road rage, paranoia, impaired delusions

Question 11

sildenafil

Answer 11

sildenafil is another namef for viagra. PDE5 inhibitor
relax smooth muscle, inc. vasodialtion & blood flow to penis

Question 12

sildenafil caution for pt who have and considerations/contraindications

-include cardiac, pressure measurement, medication contraindication ((3), diseases (5)

Answer 12

viagra (sildenafil) Caution
HF
Cardiomyopathy
Anatomic deformities
Conditions predisposing to priapism (nonstop long lasting erection)

Caution:
Protease inhibitors + sildenafil ↑ serum concentrations of sildenafil
MI, CVA, or life-threatening dysrhythmia < 6 months
Resting hypotension (BP <90/50) or hypertension (BP >170/110)
Heart failure or CAD causing unstable angina
Consideration:
Take 30 min up to 4 hours before sexual activity
Contraindication:
Nitrates (nitroglycerin) within the last 24 hours

Question 13

sildenafil (viagra) adverse effects

Answer 13

Headache **
Flushing
GI distress
Nasal congestion
Diarrhea
Sudden hearing loss**
Blurred vision
Photosensitivity
Changes in color perception (blue color tinge)
Urinary tract symptoms
Frequency
Dysuria: painful or difficult urination
Cloudy or bloody urine

Question 14

sildenafil (viagra) FDA warning

Answer 14

don’t take viagra if you had nitroglycerin within 24hrs
don’t take it if you had an MI, CVA, life-threatening dysrhytmia in under 6 months
if bp is under 90/50 and bp is over 170/110

Question 15

tamsulosin uses

Answer 15

an alpha 1 blocker
-decreases pressure around urethra and inc. urinary flow.
use in bph (benign prostatic hyperplasia)

Question 16

adverse reactions & considerations of tamsulosin

Answer 16

-adverse reactions: orthostatic hypotension, priapism, headache, dizziness, vision changes, stuffy nose

consideration: taken indefinitely, tamsulosin get worst when you stop taking it.

Question 17

finasteride (generic name is propecia)

Answer 17

convert testesterone to someone else
-shrinks the prostate
uses: BPH, male pattern baldness

Question 18

finasteride (propecia) adverse effects

Answer 18

dec libido, impotence, hirsutism, erectyle dysfunction

caution: no blood donation for a month after dose
takes months before seeing effect
pregnant women and nurses should not touch the drug

Question 19

estrogen and anti-androgens have no effect on

Answer 19

voice (m-f still have a deep male voice)
no effect on prominence of larynx

Question 20

transgender men can have both ——- and ——— as symptoms (opposite, 1 may experience once, the other can experience the other one)

Answer 20

transgender men can have both facial and body hair growth but they can also have hair loss as well)

Question 21

masculinizing hormones for transgender men

Answer 21

testesterone
injectable depo-provera
-progestin
-cessation of menses, contraception
oral/sublingual
-finasteride (propecia)
-treat baldness, may cause thinning of other body
hair, may interfere w/ clitoral enlargement

Question 22

how is spironolactone use in reproduction

Answer 22

although its a potassium sparing diuretic (water pill, remove water in your body while keeping sodium). its also an anti-androgen, it stops testosterone hormone from working.