Pharm equations Flashcards by Abbey Phelps | Brainscape

Q

Michaelis-Menten Equation

A

Effect = Emax [D] / Kd + [D]

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Q

Henderson Hasselbach Equation

A

pH = pKa + log A-/HA

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Q

Bioavailability

A

AUC oral / AUC iv X 100

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Q

Predict plasma concentration

A

Cp = dose / Vd

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Q

Limitations on bioavailabilty

A

Cp = (F x dose) / Vd f = fraction available

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Q

Velocity of metabolism

A

V = Vmax [D] / Km + [D]

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Q

If D less than Km

A

efficient enzyme - first order. v = Vmax [D] / Km

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Q

If D&raquo_space; Km

A

inefficient enzyme - zero order. v = Vmax

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Q

Margin of safety

A

TD50 - ED50

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Q

Therapeutic Index

A

TD50 / ED50

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Q

Steady state

A

Css = dose/delta t (mg/min) / clearance

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Q

GFR

A

120 ml/min

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Q

Half Life equation

A

t 1/2 = 0.693 X Vd / Cl OR t 1/2 = 0.693/Ke

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Q

Elimination Rate Constant equation

A

Ke = clearance/Vd OR Ke = 0.693/t 1/2

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